| 经胆管192Ir内照射对犬胆管周围肝组织放射损伤的实验研究 |
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| 引用本文： | 曹贵文,王滨,隋守光,孙业全.经胆管192Ir内照射对犬胆管周围肝组织放射损伤的实验研究[J].医学影像学杂志,2007,17(11):1213-1216. |
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| 作者姓名： | 曹贵文 王滨 隋守光 孙业全 |
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| 作者单位： | 1. 潍坊医学院附属医院影像中心,山东,潍坊,261041
2. 胜利油田中心医院影像中心介入室,山东,东营,257034 |
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| 摘 要： | 目的:通过研究经胆管192Ir内照射(192Ir-internalirradiation,192 Ir-IIR)对胆管周围肝组织放射损伤,探讨经胆管192 Ir-IIR的有效治疗范围。方法:实验动物为雄性健康杂种犬4只,体重25~30kg。经手术将施源管植入胆管,根据预先设定的剂量及照射点进行胆管内近距离照射。放射源采用192Ir。内照射10天后处死动物,距离胆管壁由近及远按设计距离分别取1mm×1mm×1mm大小肝组织,常规制备光镜切片,作TUNEL染色;同时常规制备电镜切片。光镜下观察周围肝组织的放射损伤同时计数凋亡肝细胞。电镜下观察肝组织超微结构损伤变化并计数凋亡肝细胞。结果:在胆管最大耐受剂量50Gy时,距胆管15mm内肝细胞核出现不可逆性改变。结论:距放射源15mm可以作为有效治疗范围。
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| 关 键 词： | 192Ir内照射 放射损伤 胆管周围肝组织 |
| 文章编号： | 1006-9011（2007）11-1213-04 |
| 修稿时间： | 2007-09-10 |
The acute radiation injury on liver tissue near bile duct of dog by 192Ir-internal irradiation through bile duct: an experimental study |
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| CAO Gui-wen,WANG Bin,SUI Shou-guang,SUN Ye-quan.The acute radiation injury on liver tissue near bile duct of dog by 192Ir-internal irradiation through bile duct: an experimental study[J].Journal of Medical Imaging,2007,17(11):1213-1216. |
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| Authors: | CAO Gui-wen WANG Bin SUI Shou-guang SUN Ye-quan |
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| Institution: | 1. Medical Imaging Center of The Affilated Hospital, Weifang Medical University, Welfang Shandong 261041, P. R. China 2. Medical Imaging Center of The Shengli Oilfield Ceraral Hospital, Dongying Shandong 257034, P. R. China |
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| Abstract: | |
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| Keywords: | 192Ir-internal irradiation Radiation injury Liver tissue near bile duct |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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