肝脏局灶性病变MRI表现与病理学的相关性研究

肝脏局灶性病变的MRI信号强度受许多病理因素的影响。病变的组织学特征:细胞构成、血液供应、间质构成和肿瘤内的坏死或者出血等,都会使病变的T1及T2弛豫时间发生显著变化。细胞内的某些内容物:糖原、脂肪、黑色素、铁和铜,在决定MRI信号表现方面起着重要的作用。MRI与病理学之间联系的研究对于诊断局灶性病变非常有帮助。

MRI manifesfations of focal liver lesions: possible relations to pathological findings

MR signal intensity of focal liver lesion is affected by numerous pathologic factors.Histologic features of lesions,such as cellularity,vascularity,stromal component,and intratumoral necrosis or hemorrhage,strongly affect T1 and T2 relaxation times.Additionally,intracellular content of certain substance,such as glycogen,fat,melain,iron,and copper,may also have a substantial role in determining MR signal behavior.In this review,we discuss the correlations between MR imaging features and pathologic findings in benign and malignant focal liver lesions.Knowledge of imaging-pathology correlations greatly assist in characterizing focal lesions.Moreover,such as hepatocellular carcinoma,careful analysis of lesion signal intensity may help predict the degree of tumor differentiation.