| RP—HPLC法测定咳欣康片中吗啡的含量 |
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| 引用本文： | 董海荣,李君,李俊芳,毛洪雨.RP—HPLC法测定咳欣康片中吗啡的含量[J].辽宁中医学院学报,2009(11):187-188. |
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| 作者姓名： | 董海荣 李君 李俊芳 毛洪雨 |
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| 作者单位： | 承德颈复康药业集团有限公司,河北承德067000 |
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| 摘 要： | 目的：采用高效液相色谱法测定咳欣康片中吗啡含量。方法：采用InertsilODS-3C185μm（250mm×4．6mm）柱，以甲醇-0．5％醋酸铵-三乙胺（30：70：0．1）为流动相，流速为1mL／min，检测波长为220nm。结果：吗啡在0．1188-1．188μg与峰面积线性关系良好，r=0．9999，平均回收率为97．74％，RSD为0．87％。结论：该方法操作简便，精密度好，结果准确可靠。
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| 关 键 词： | 反相高效液相色谱法 咳欣康片 吗啡 含量测定 |
Content Determination of Morphine in Kexinkang Tablets by RP-HPLC |
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| DONG Hai-rong,LI Jun,LI Jun-fang,MAO Hong-yu.Content Determination of Morphine in Kexinkang Tablets by RP-HPLC[J].Journal of Liaoning College of Traditional Chinese Medicine,2009(11):187-188. |
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| Authors: | DONG Hai-rong LI Jun LI Jun-fang MAO Hong-yu |
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| Institution: | ( Chengde Jingfukang Pharmaceutical Group Co., Ltd, Chengde 067000, Hebei, China ) |
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| Abstract: | Objective：To determine morphine in Kexinkang tablets by RP-HPLC .Methods： Using Inertial ODS-3 C 18 5 μm（ 250mm × 4.6mm ）column, Methanol-ammonium acetate-triethylamine（30：70：0.1） as mobile phase. The flow rate was 1 mL/min, the detection wavelength was 220nm. Results： The calibration curve was linear in the range of 0.1188-1.188 μg for protopine（r=0.9999）.The average recovery （n=9） was 97.74%, and RSD was 0.87%.Conclusion： The method is rapid, accurate and reliable. |
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| Keywords: | RP-HPLC Kexinkang Tablets Morphine Content Determination |
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