| 宫颈组织中Th、树突状细胞及自然杀伤细胞的表达及与免疫功能的关系 |
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| 引用本文： | 马翠,张为远,王建东. 宫颈组织中Th、树突状细胞及自然杀伤细胞的表达及与免疫功能的关系[J]. 中华医学杂志, 2009, 89(23): 1650-1653. DOI: 10.3760/cma.j.issn.0376-2491.2009.23.019 |
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| 作者姓名： | 马翠 张为远 王建东 |
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| 作者单位： | 首都医科大学附属北京妇产医院,100026 |
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| 基金项目： | 北京市科学技术委员会重大项目 |
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| 摘 要： | 目的 探讨正常宫颈、CIN、宫颈癌组织的局部免疫功能差异及HPV感染与宫颈局部免疫功能的关系.方法 采用免疫组化和图像分析技术,通过CD4、S-100、CD57抗体测定正常宫颈组织、CIN宫颈组织、宫颈癌组织中Th细胞、树突状细胞、NK细胞的形态、数量、分布及表达强度.结果 在癌前病变中,CD4+ Th细胞、S-100+ DC细胞和CD57+ NK细胞随着病变加重而逐渐增多(P<0.05),表达强度增大;而在发生癌变之后,宫颈局部的免疫细胞减少(P<0.05),表达强度下降.结论 人宫颈癌前病变组织局部的免疫功能比较活跃,而癌变的组织免疫功能降低.
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| 关 键 词： | 宫颈上皮内瘤变 宫颈癌 免疫组织化学 |
Expressions of Th, DC, NK cells in cervical tissue and the relationship with immune functions |
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| MA Cui,ZHANG Wei-yuan,WANG Jian-dong. Expressions of Th, DC, NK cells in cervical tissue and the relationship with immune functions[J]. Zhonghua yi xue za zhi, 2009, 89(23): 1650-1653. DOI: 10.3760/cma.j.issn.0376-2491.2009.23.019 |
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| Authors: | MA Cui ZHANG Wei-yuan WANG Jian-dong |
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| Abstract: | Objective To investigate the different immune functions in normal cervix, CIN and cervical cancer tissue and the ralationship between HPV infection and local cervical immune functions. Methods The morphology, quantity, distribution and optical density of CD4+ Th cells, S-100+ dendritic cells and CD57+ NK cells in normal cervical tissue, CIN cervical tissue and cervical cancer tissue were determined by immunohistochemistry and imaging analysis. Results In the precancerous lesions, the numbers of the CD4+ Th cells, S-100+ DC and CD57+ NK cells increased with the disease progression in CIN (P<0.05). But, after carcinogenesis, the immune cells decreased in local cervix tissue (P<0.05). Conclusion The local tissue of human cervical precancerous lesions had more heightened immune functions as compared with the cancer tissue. |
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| Keywords: | Cervical intraepithelial neoplasia Cervical cancer Immunohistochemistry |
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