| 趋化因子与中枢神经系统感染 |
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| 引用本文： | 张静,邓向红. 趋化因子与中枢神经系统感染[J]. 临床医学工程, 2014, 0(5): 668-669 |
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| 作者姓名： | 张静 邓向红 |
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| 作者单位： | 1. 中山大学中山医学院,广东广州510080; 广东省中山市人民医院普通儿科,广东中山528403
2. 广东省中山市人民医院普通儿科,广东中山,528403 |
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| 摘 要： | 趋化因子(chemokine)是一类具有化学趋化活性的细胞因子家族。在中枢神经系统(central nerve system,CNS)感染时,趋化因子及其受体可介导炎性细胞穿越血脑屏障(blood-brain barrier,BBB)浸润到病灶部位。因此,对趋化因子在中枢神经系统感染中的深入研究不仅能了解疾病的发病机制,也能提供可能的药物治疗靶点。
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| 关 键 词： | 趋化因子 趋化因子受体 中枢神经系统感染 |
Chemokines and Central Nerve System Infection |
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| ZHANG Jing,DENG Xianghong. Chemokines and Central Nerve System Infection[J]. Medical and Health Care Instruments, 2014, 0(5): 668-669 |
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| Authors: | ZHANG Jing DENG Xianghong |
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| Affiliation: | ZHANG Jing, DENG Xianghong (lZhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China; 2Department of Pediatrics, Zhongshan People＇s Hospital, Zhongshan 528403, China; |
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| Abstract: | Chemokines are a class of cytokines family which have chemotactic activity. Chemokines and their receptors can mediate inflammatory cells to cross blood-brain barrier（BBB） to lesions when central nerve system（CNS） get infected. Accordingly, studying the interaction among chemokines, their receptors and CNS infection can not only understand the pathogenesis of diseases, but also offer some possible drug treatment targets. |
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| Keywords: | Chemokine Chemokine receptor Central nerve system infection |
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