Change of cross-linked telopeptide of type I collagen (ICTP) and other bone resorption markers in patients with bone fragility fractures |
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Authors: | Kenji Takahara Mikio Kamimura Hiroyuki Hashidate Shigeharu Uchiyama Hiroyuki Nakagawa |
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Institution: | (1) Department of Orthopedic Surgery, Suwa Red Cross Hospital, Suwa, Japan;(2) Center of Osteoporosis and Spinal Disorders, Kamimura Orthopaedic Clinic, Nagano, Japan;(3) Department of Orthopedic Surgery, Ina Central Hospital, Ina, Nagano 396-8555, Japan |
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Abstract: | Background The serum concentration of cross-linked telopeptide of type I collagen (ICTP) has been reported to be a useful marker and
for both diagnosis and monitoring of bone metastasis. This study was performed to clarify the changes in various bone turnover
markers, including ICTP, after bone fragility fracture.
Methods Seventy-six bone fragility fracture patients (14 men and 62 postmenopausal women; mean age, 77.0 years) were evaluated for
bone resorption markers, including serum ICTP. We measured urinary N-terminal telopeptides of type I collagen (NTX) several
times after fracture. Furthermore, serum ICTP, serum NTX, urinary deoxypyridinoline (DPD), and urinary C-telopeptide-cross-linked
type I collagen (CTX) were measured at the times of both minimum and maximum urinary NTX.
Results Urinary NTX was increased significantly from 86.4 ± 57.9 to 214.3 ± 137.2 nmol BCE/mmol Cr following fracture. Serum ICTP
showed a similar significant increase from 7.6 ± 4.7 to 10.4 ± 5.5 ng/ml in bone fragility fracture patients. Furthermore,
other markers also showed similar increases. The level of increase in urinary NTX (148.0%) was especially high compared with
other bone resorption markers. On the other hand, the level of increase in serum ICTP (36.8%) was similar to that in serum
NTX (39.8%). Serum ICTP levels were significantly correlated with other bone resorption markers, with an especially strong
correlation between serum ICTP and serum NTX (r = 0.647, P < 0.001). The percentage of cases in which ICTP exceeded the cutoff value for suspected bone metastasis in postmenopausal
women was 73.6%.
Conclusions The value of ICTP increases with bone fragility fracture and is correlated with other bone resorption markers, and ICTP obviously
exceeded the reference value as compared with other bone resorption markers. |
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