Effect of simvastatin on restenosis after percutaneous transluminal angioplasty of femoropopliteal arterial obstruction |
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Authors: | Hagenaars T Gussenhoven E J van Sambeek M R Jukema J W Kranendonk S E Bom N |
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Affiliation: | Department of Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands. hagenaars@tch.fgg.eur.nl |
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Abstract: | This retrospective observational intravascular ultrasound study evaluated whether simvastatin therapy limits lumen area reduction 1-year after percutaneous transluminal angioplasty (PTA) by reducing reactive plaque growth, reducing reactive vasoconstriction, or both. This study showed that plaque growth is a general response 1 year after PTA regardless of the use of simvastatin; simvastatin has the potential to induce positive vascular remodeling, thereby reducing the occurrence of restenosis. |
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