| 金丝桃苷对CCl_4诱导的大鼠肝损伤的保护作用研究 |
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| 引用本文： | 唐敏,刘耀,夏培元.金丝桃苷对CCl_4诱导的大鼠肝损伤的保护作用研究[J].中国药房,2011(7):582-583. |
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| 作者姓名： | 唐敏 刘耀 夏培元 |
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| 作者单位： | 第三军医大学第一附属医院药学部; |
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| 基金项目： | 国家自然科学基金资助项目(30572366) |
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| 摘 要： | 目的:研究金丝桃苷(hyperfine,HP)对CCl4诱导的大鼠肝损伤的保护作用。方法:连续3d对大鼠灌胃给予不同剂量的HP,并于末次给药6h后灌胃给予CCl4复制急性肝损伤模型,24h测定血清丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)及肝组织匀浆中丙二醛(MDA)含量和超氧化物歧化酶(SOD)、谷胱甘肽(GSH)活性;同时进行肝组织病理学观察。结果:不同剂量的HP可显著降低模型大鼠血清中ALT、AST,肝组织匀浆中MDA含量;显著升高SOD、GSH活性;病理切片表明,HP预处理组肝组织损伤均有不同程度减轻,其中以30mg·kg-1剂量效果最佳。结论:HP对CCl4诱导的大鼠急性肝损伤具有较好的保护作用,其作用机制可能与HP抑制抗氧化酶活性和抗自由基活性有关。
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| 关 键 词： | 金丝桃苷 四氯化碳 急性肝损伤 保肝作用 |
Protective Effect of Hyperfine on Acute Liver Injury in Rats Induced by CCl_4 |
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| TANG Min,LIU Yao,XIA Pei-yuan.Protective Effect of Hyperfine on Acute Liver Injury in Rats Induced by CCl_4[J].China Pharmacy,2011(7):582-583. |
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| Authors: | TANG Min LIU Yao XIA Pei-yuan |
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| Institution: | TANG Min,LIU Yao,XIA Pei-yuan(Dept. of Pharmacy,The First Affialited Hospital of Third Military Medical University,Chongqing 400038,China) |
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| Abstract: | OBJECTIVE: To study the protective effect of hyperfine (HP) on the acute liver injury in rats induced by CCl4. METHODS: Different dosage of HP was given to rats intragastrically for 3 days. Acute liver injury was induced by CCl4 with intragastric administration 6 h after last administration. After 24 hours, the content of ALT and AST in the serum, MDA content, the activity of SOD and GSH in the liver homogenate were determined. At the same time, the pathological observation of liver tissues was conducted. R... |
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| Keywords: | Hyperine CCl4 Acute liver injury Liver protection |
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