| 不同微生态制剂联合奥沙拉嗪对轻中度溃疡性结肠炎的治疗作用 |
| |
| 引用本文： | 张彩凤,李贞娟,艾芳,夏永华,郜庆祖,秦咏梅,韩宇.不同微生态制剂联合奥沙拉嗪对轻中度溃疡性结肠炎的治疗作用[J].中国药房,2011(14). |
| |
| 作者姓名： | 张彩凤 李贞娟 艾芳 夏永华 郜庆祖 秦咏梅 韩宇 |
| |
| 作者单位： | 新乡医学院第一附属医院消化内科;新乡医学院第一附属医院病理科; |
| |
| 基金项目： | 河南省教育厅科研项目(20073200143) |
| |
| 摘 要： | 目的:观察不同微生态制剂联合奥沙拉嗪对轻中度溃疡性结肠炎(慢性复发型,活动期)的临床疗效。方法:采用随机、对照设计,将60例轻中度溃疡性结肠炎患者随机分为3组,即金双歧组(金双歧+奥沙拉嗪)、美常安组(美常安+奥沙拉嗪)、奥沙拉嗪组(单纯使用奥沙拉嗪),每组20例。比较3组患者治疗前后临床症状评分、结肠炎症评分、结肠镜下分级评分及分析粪便菌群,疗程为24个月,随访48个月。粪便菌群分析设正常对照组。结果:金双歧组、美常安组的临床症状评分、结肠炎症评分、结肠镜下分级评分及粪便菌群分析情况均明显优于奥沙拉嗪组,且金双歧组优于美常安组。随访48个月,金双歧组未见复发,美常安组有3例复发,奥沙拉嗪组有18例复发。结论:微生态制剂联合奥沙拉嗪治疗溃疡性结肠炎的疗效明显优于单纯使用奥沙拉嗪。
|
| 关 键 词： | 溃疡性结肠炎 菌群 微生态制剂 |
Therapeutic Efficacy of Different Probiotic Preparations Combined with Olsalazine in the Treatment of Mild and Moderate Ulcerative Colitis |
| |
| ZHANG Cai-feng,LI Zhen-juan,AI Fang,XIA Yong-hua,QIN Yong-mei,HAN YuGAO Qing-zu.Therapeutic Efficacy of Different Probiotic Preparations Combined with Olsalazine in the Treatment of Mild and Moderate Ulcerative Colitis[J].China Pharmacy,2011(14). |
| |
| Authors: | ZHANG Cai-feng LI Zhen-juan AI Fang XIA Yong-hua QIN Yong-mei HAN YuGAO Qing-zu |
| |
| Institution: | ZHANG Cai-feng,LI Zhen-juan,AI Fang,XIA Yong-hua,QIN Yong-mei,HAN Yu(Dept.of Gastroenterology,The First Affiliated Hospital of Xinxiang Medical College,Weihui 453100,China)GAO Qing-zu(Dept.of Pathology,China) |
| |
| Abstract: | OBJECTIVE:To observe clinical efficacy of different probiotic preparations combined with olsalazine for mild and moderate ulcerative colitis.METHODS:In randomized controlled study,a total of 60 patients with mild and moderate ulcerative colitis were randomly divided into 3 groups,i.e.Jinshuanqi group(Jinshuanqi +olsalazine),Meichang'an group(Meichang'an+Olsalazine),Olsalazine group(Olsalazine) with each group of 20 cases.The clinical symptom score,colon mucosa inflammation score and endoscopic grade score w... |
| |
| Keywords: | Ulcerative colitis Microbiota Probiotic preparations |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
