| 国产与进口阿立哌唑治疗精神分裂症的疗效及安全性对照研究 |
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| 引用本文： | 邱堂威,朱怀轩,黎俊华.国产与进口阿立哌唑治疗精神分裂症的疗效及安全性对照研究[J].中国药房,2011(18):1699-1701. |
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| 作者姓名： | 邱堂威 朱怀轩 黎俊华 |
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| 作者单位： | 重庆市精神病院;遵义医学院附属医院; |
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| 摘 要： | 目的:比较国产与进口阿立哌唑治疗精神分裂症的疗效及安全性。方法:72例精神分裂症患者随机分为国产组与进口组,分别给予国产阿立哌唑片、进口阿立哌唑片治疗,观察疗程为8周。入组时和治疗后第2、4、6、8周,采用阳性和阴性症状量表(PANSS)进行疗效评估;在治疗前和试验结束时,用副反应量表(TESS)、心电图、实验室检查等进行安全性评估。结果:国产组与进口组的有效率分别为73.5%、74.2%(P>0.05)。与治疗前比较,治疗第8周末2组的阳性量表分、阴性量表分、一般精神病理症状量表分、PANSS总分均显著下降(P<0.01)。治疗期间2组均未发生严重不良事件,国产组与进口组副反应总发生率分别为41.2%、38.7%(P>0.05)。结论:国产阿立哌唑治疗精神分裂症的疗效与进口阿立哌唑相当,安全性良好。
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| 关 键 词： | 精神分裂症 阿立哌唑 疗效 安全性 |
Comparative Study of Therapeutic Efficacy and Safety of Domestic vs.Imported Aripiprazole in the Treatment of Schizophrenia |
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| QIU Tang-wei,ZHU Huai-xuan LI Jun-hua.Comparative Study of Therapeutic Efficacy and Safety of Domestic vs.Imported Aripiprazole in the Treatment of Schizophrenia[J].China Pharmacy,2011(18):1699-1701. |
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| Authors: | QIU Tang-wei ZHU Huai-xuan LI Jun-hua |
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| Institution: | QIU Tang-wei,ZHU Huai-xuan(Chongqing Psychiatry Hospital,Chongqing 400038,China) LI Jun-hua(The Affiliated Hospital of Zunyi Medical College,Zunyi 563003,China) |
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| Abstract: | OBJECTIVE:To compare the therapeutic efficacy and safety of domestic vs.imported aripiprazole in the treatment of schizophrenia.METHODS:72 schizophrenia patients were randomly divided into domestic aripiprazole group and imported aripiprazole group.Two groups were given domestic Aripiprazole tablets or imported Aripiprazole tablets for 8 weeks.The therapeutic efficacies of two groups were evaluated using Positive and Negative Symptoms Scale (PANSS) before treatment and 2,4,6,8 weeks after treatment.Treatmen... |
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| Keywords: | Schizophrenia Aripiprazole Therapeutic efficacy Safety |
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