| 匹伐他汀对2型糖尿病脂代谢紊乱的调脂作用研究 |
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| 引用本文： | 郭莲,刘维娟,徐伟,栾建芳,罗涌. 匹伐他汀对2型糖尿病脂代谢紊乱的调脂作用研究[J]. 中国药房, 2011, 0(18): 1696-1698 |
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| 作者姓名： | 郭莲 刘维娟 徐伟 栾建芳 罗涌 |
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| 作者单位： | 重庆三峡中心医院内分泌科; |
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| 摘 要： | 目的:研究匹伐他汀对2型糖尿病脂代谢紊乱的调脂作用。方法:80例2型糖尿病脂代谢紊乱患者随机分为对照组与治疗组,各40例,在常规治疗基础上,对照组加用洛伐他汀片,治疗组加用匹伐他汀钙片,疗程12周。考察治疗前、后血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、糖化血红蛋白(HbA1c)、血压(BP)、心率(HR)及体重指数(BMI)、天门冬酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、γ-谷氨酰转移酶(GGT)的变化。结果:2组治疗后TC、TG、LDL-C均较治疗前明显下降(P<0.05),治疗组的降低程度更大,差异有统计学意义(P<0.05)。2组治疗后HDL-C均较治疗前明显提高(P<0.05),治疗组的升高程度更大,差异有统计学意义(P<0.05)。2组治疗后HbA1c、收缩压(SBP)、HR、BMI及AST、ALT均下降,但治疗前、后及治疗后2组间比较差异均无统计学意义(P>0.05)。与对照组比较,治疗组GGT升高,但差异无统计学意义(P>0.05)。结论:匹伐他汀可改善2型糖尿病患者的脂代谢紊乱状态,对血糖、血压、HR、BMI及肝酶谱无明显影响。
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| 关 键 词： | 匹伐他汀 糖尿病 脂代谢紊乱 |
Clinical Study of Pitavastatin in the Treatment of Type 2 Diabetes Dyslipidoses |
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| GUO Lian,LIU Wei-juan,XU Wei,LUAN Jian-fang,LUO Yong. Clinical Study of Pitavastatin in the Treatment of Type 2 Diabetes Dyslipidoses[J]. China Pharmacy, 2011, 0(18): 1696-1698 |
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| Authors: | GUO Lian LIU Wei-juan XU Wei LUAN Jian-fang LUO Yong |
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| Affiliation: | GUO Lian,LIU Wei-juan,XU Wei,LUAN Jian-fang,LUO Yong(Dept.of Endocrinology,Chongqing Three Gorges Central Hospital,Chongqing 404000,China) |
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| Abstract: | OBJECTIVE:To observe the clinical efficacy and safety of pitavastatin in the treatment of type 2 diabetes dyslipidoses.METHODS:80 patients with type 2 diabetes dyslipidoses were randomly divided into control group and treatment group with each group of 40 cases.On the basis of conventional treatment,control group was additional treated with Lovastatin tablets,and treatment group was treated with Pitavastatin tablets for 12 weeks.The changes of blood cholesterol (TC),triglyceride (TG),low density lipoprotein... |
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| Keywords: | Pitavastatin Diabetes Dyslipidoses |
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