| 夏天无总碱多囊脂质体的制备与体外特征评价 |
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| 引用本文： | 刘芬,李良,钟海军,黄惠明,郭峰,徐春莲,徐卫国.夏天无总碱多囊脂质体的制备与体外特征评价[J].中国药房,2011(7):605-607. |
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| 作者姓名： | 刘芬 李良 钟海军 黄惠明 郭峰 徐春莲 徐卫国 |
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| 作者单位： | 南昌大学医学院药学系;武警江西总队医院药剂科;江西天施康中药股份有限公司; |
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| 基金项目： | 江西省科技计划工业领域重点项目(2007BG13105) |
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| 摘 要： | 目的:制备夏天无总碱多囊脂质体,并进行体外特征评价。方法:以包封率为评价指标,以卵磷脂(PC)与药物、PC与三油酸甘油酯(TO)、PC与磷脂酰丝氨酸(PS)、PC与胆固醇(CH)的质量比为考察因素,用复乳法制备夏天无总碱多囊脂质体;并考察其形态、粒径和体外释放行为。结果:PC与药物、PC与TO、PC与PS、PC与CH的质量比分别为10∶2、3∶1、4∶3、1∶2.5,包封率可达(50±3)%;多囊脂质体呈球状体,平均粒径为22.0μm,在生理盐水中体外释放时间可持续2d。结论:该制备工艺稳定、可行。
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| 关 键 词： | 夏天无总碱 多囊脂质体 制备 体外评价 缓释 |
Preparation and in Vitro Evaluation of Corydalis decumbens Total Alkali Multivesicular Liposomes |
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| LIU Fen,ZHONG Hai-jun,HUANG Hui-ming,GUO Feng,XU Chun-lian LI Liang XU Wei-guo.Preparation and in Vitro Evaluation of Corydalis decumbens Total Alkali Multivesicular Liposomes[J].China Pharmacy,2011(7):605-607. |
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| Authors: | LIU Fen ZHONG Hai-jun HUANG Hui-ming GUO Feng XU Chun-lian LI Liang XU Wei-guo |
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| Institution: | LIU Fen,ZHONG Hai-jun,HUANG Hui-ming,GUO Feng,XU Chun-lian(Dept. of Pharmacy,Medical College of Nanchang University,Nanchang 330006,China) LI Liang(Dept. of Pharmacy,Jiangxi Hospital,Jinangxi Corps of Chinese Armed Police Force,Nanchang 330001,China) XU Wei-guo(Jiangxi Herbi-sky Co.,Ltd.,Yingtan 335000,China) |
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| Abstract: | OBJECTIVE: To prepare Corydalis decumbens total alkali multivescular liposomes and evaluate it in vitro. METHODS: C. decumbens total alkali multivescular liposomes were prepared by multiple emulsion method with encapsulation efficiency as index and with ratio of phospgatidycholine (PC) to drugs, ratio of PC to triolein (TO), ratio of OC to phosphatidylserine (PS) and ratio of PC to cholesterin (CH) as factors. The morphology, particle size, release in vitro of preparation were evaluated. RESULTS: The ratio ... |
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| Keywords: | Corydalis decumbens Multivescular liposomes Preparation Evaluation in vitro Sustained release |
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