| 胸腺五肽脂质体的研制 |
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| 引用本文： | 裴斐,宋宏新,张凤龙,赵金礼.胸腺五肽脂质体的研制[J].中国药房,2011(17):1595-1597. |
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| 作者姓名： | 裴斐 宋宏新 张凤龙 赵金礼 |
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| 作者单位： | 陕西科技大学生命科学与工程学院;陕西九州生物科技股份有限公司; |
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| 摘 要： | 目的:制备胸腺五肽脂质体并进行质量评价。方法:采用复乳法制备胸腺五肽脂质体,以聚乳酸-羟基乙酸共聚物(PLGA)及卵磷脂为成球材料、以胸腺五肽为主药制备脂质体。以明胶浓度、PLGA浓度和卵磷脂浓度为考察因素,以包封率和载药量为考察指标设计L(934)正交试验优化基质处方并进行验证试验。通过测定优化处方所制脂质体粒径、包封率、体外累积释放百分率等评价脂质体质量。结果:优化基质处方为明胶、PLGA和卵磷脂浓度分别为100、200、100mg.mL-1。所制脂质体形态完整,平均粒径为(9.03±0.83)μm,载药量与包封率分别为(1.81±0.03)与(74.4±1.4),20d的累积释药百分率达90以上。结论:所制胸腺五肽脂质体工艺简单、重现性好,包封率和载药量高,具有显著的缓释作用。
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| 关 键 词： | 胸腺五肽 聚乳酸-羟基乙酸共聚物 脂质体 制备 优化基质处方 正交试验 质量评价 |
Study and Preparation of Thymopentin Liposomes |
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| PEI Fei,SONG Hong-xin ZHANG Feng-long,ZHAO Jin-li.Study and Preparation of Thymopentin Liposomes[J].China Pharmacy,2011(17):1595-1597. |
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| Authors: | PEI Fei SONG Hong-xin ZHANG Feng-long ZHAO Jin-li |
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| Institution: | PEI Fei,SONG Hong-xin(College of Life Science and Engineering,Shaanxi University of Science and Technology,Xi'an 710021,China) ZHANG Feng-long,ZHAO Jin-li(Shaanxi Jiuzhou Biotechnology Co.,Ltd.,Xi'an 710075,China) |
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| Abstract: | OBJECTIVE:To prepare thymopentin liposomes and to evaluate the quality of it.METHODS:Thymopentin liposomes were prepared by double emulsion process using poly(lactic-co-glycolic acid)(PLGA) and lecithin as carrier and thymopentin as main components.The preparation method was optimized by orthogonal experiment L9(34) using the concentration of gelatin,PLGA and lecithin as factors and with encapsulation coefficency and drug loading capacity as index.The particle size,encapsulation coefficency and in vitro acc... |
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| Keywords: | Thymopentin Poly(lactic-co-glycolic acid) Liposomes Preparation Optimal base formula Orthogonal experiment Quality evaluation |
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