| 洋葱挥发油抗肿瘤作用的实验研究 |
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| 引用本文： | 方阅,刘皋林,张渊. 洋葱挥发油抗肿瘤作用的实验研究[J]. 中国药房, 2011, 0(7): 592-594 |
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| 作者姓名： | 方阅 刘皋林 张渊 |
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| 作者单位： | 上海市第一人民医院药剂科; |
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| 摘 要： | 目的:研究洋葱挥发油离体对人肝癌细胞株(QCY-7703)、人胃癌细胞株(MGC-803)、人宫颈癌细胞株(Hela)、人肺腺癌细胞株(SPC-A-1)的增殖抑制作用和在体对小鼠肉瘤S180及小鼠艾氏腹水癌的抑制作用。方法:采用MTT法检测不同剂量的洋葱挥发油对4种肿瘤细胞增殖的影响,复制小鼠肉瘤S180和小鼠艾氏腹水癌模型,检测不同剂量(1000、500、250mg·kg-1)的洋葱挥发油对小鼠肿瘤的抑制作用,比较其抑制率。结果:洋葱挥发油离体和在体实验中对肿瘤细胞均具有较强的增殖抑制作用。结论:洋葱挥发油能抑制多种肿瘤细胞的增殖,对肿瘤细胞有明显的细胞毒性作用。
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| 关 键 词： | 洋葱挥发油 体内 体外 抗肿瘤活性 |
Anticancer Effect of Volatile Oil Extracts of Allium cepa |
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| FANG Yue,LIU Gao-lin,ZHANG Yuan. Anticancer Effect of Volatile Oil Extracts of Allium cepa[J]. China Pharmacy, 2011, 0(7): 592-594 |
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| Authors: | FANG Yue LIU Gao-lin ZHANG Yuan |
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| Affiliation: | (Dept. of Pharmacy, Shanghai Municipal First People＇ s Hospital, Shanghai 200080, China) |
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| Abstract: | OBJECTIVE:To study the in vitro inhibition effect of volatile oil extracts of Allium cepa on the proliferation of QCY-7703, MGC-803, Hela, SPC-A-1 cells and the in vivo inhibition effect on sarcoma S180 and Ehrlich ascites carcinoma in mice. METHODS: MTT assay was used to detect the effect of volatile oil extracts of A. cepa with different dose on the proliferation of 4 kinds of tumor cells. We established sarcoma S180 and ehrlich ascites carcinoma model, detected the inhibition effect of volatile oil extra... |
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| Keywords: | Volatile oil extracts of Allium cepa In vivo In vitro Anticancer effect |
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