| 延衰合剂对D-半乳糖衰老小鼠血清SOD、MDA、IL-2和睾酮的影响 |
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| 引用本文： | 栾增强,曹文富,黄和贤,李志强. 延衰合剂对D-半乳糖衰老小鼠血清SOD、MDA、IL-2和睾酮的影响[J]. 中国药房, 2011, 0(7): 589-591 |
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| 作者姓名： | 栾增强 曹文富 黄和贤 李志强 |
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| 作者单位： | 重庆医科大学附属第一医院中西医结合科; |
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| 基金项目： | （致谢：感谢重庆市眼科学重点实验室在实验中给予的帮助!） |
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| 摘 要： | 目的:研究延衰合剂(Yanshuai Mixture,YSM)对D-半乳糖诱导的亚急性衰老模型小鼠血清抗氧化指标、白细胞介素-2(IL-2)和睾酮(TS)水平的影响。方法:60只小鼠随机分为正常对照(N)、模型(M)、补肾益寿胶囊(BSYS)和YSM高、中、低剂量(YSM-H、YSM-M、YSM-L)组,用D-半乳糖连续皮下注射复制衰老小鼠模型,同时给予YSM连续灌胃8周。测定血清总抗氧化能力(T-AOC)、超氧化物歧化酶(SOD)活性、丙二醛(MDA)含量;酶联免疫吸附法(ELISA)检测血清IL-2和TS的变化。结果:与N组比较,M组小鼠血清T-AOC、SOD活性显著降低,MDA含量显著增加,血清IL-2、TS水平显著降低(P<0.05);与M组比较,YSM-H组小鼠血清T-AOC、SOD显著增加,MDA含量显著减少(P<0.05);YSM各剂量组血清IL-2、TS水平显著增加(P<0.05)。结论:YSM可以显著提高D-半乳糖衰老小鼠血清抗氧化能力,抑制IL-2和TS水平的下降,可能具有良好的延缓衰老的作用。
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| 关 键 词： | 延衰合剂 衰老 抗氧化 白细胞介素-2 睾酮 |
Effects of Yanshuai Mixture on Serum SOD, MDA, IL-2 and Testosterone of Aging Mice Induced by D-galactose |
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| LUAN Zeng-qiang,CAO Wen-fu,HUANG He-xian,LI Zhi-qiang. Effects of Yanshuai Mixture on Serum SOD, MDA, IL-2 and Testosterone of Aging Mice Induced by D-galactose[J]. China Pharmacy, 2011, 0(7): 589-591 |
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| Authors: | LUAN Zeng-qiang CAO Wen-fu HUANG He-xian LI Zhi-qiang |
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| Affiliation: | LUAN Zeng-qiang,CAO Wen-fu,HUANG He-xian,LI Zhi-qiang(Dept. of Integrated Traditional Chinese Medicine and Western Medicine,The First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China) |
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| Abstract: | OBJECTIVE: To study the effects of Yanshuai mixture (YSM) on serum antioxidant index, interleukin-2 (IL-2) and testosterone (TS) levels of D-galactose induced subacute aging mice. METHODS: 60 mice were randomly divided into normal control group (N), aging model group (M), Bushen yishou capsule group (BSYS),YSM low (YSM-L), medium (YSM-M) and high (YSM-H) dose groups. The subacute aging model mice were induced by injecting with D-galactose subcutaneously. At the same time, YSM were administered intragastrica... |
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| Keywords: | Yanshuai mixture Aging Antioxidation Interleukin-2 Testosterone |
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