The cortisol response to desipramine in endogenous depressives and normal controls: preliminary findings |
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Authors: | G M Asnis U Halbreich H Rabinovich N D Ryan E J Sachar B Nelson J Puig-Antich H Novacenko |
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Affiliation: | 1. Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA;2. Neuroendocrine Laboratory College of Physicians and Surgeons, New York, NY, USA |
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Abstract: | Plasma cortisol levels were monitored for 2 hours after an intramuscular injection of 75 mg desipramine in 13 endogenous depressives and 20 normal controls. Endogenous depressives had a significantly reduced cortisol response in comparison to normal controls, not explained by sex, age, or baseline cortisol differences between groups. A lack of a cortisol rise of 1.5 micrograms/dl above baseline by 45 minutes discriminated best, with 7 of 13 depressives (55%) being identified in contrast to only 1 of 20 normals (5%). The results suggest that this may be a useful biological test with acceptable sensitivity (55%) and excellent specificity (95%). Furthermore, these data suggest that norepinephrine may be stimulatory to cortisol in man. |
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Keywords: | Desipramine cortisol norepinephrine endogenous depression |
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