Preliminary findings on calmodulin-stimulated Ca2+-ATPase of erythrocyte ghosts in psychotic patients

Summary Kinetic properties of the calmodulin-stimulated erythrocyte ghost Ca²⁺-ATPase seem to be altered in some sub-groups of affective and schizophrenic psychoses. The subgroup of affective disorders concerned mostly unipolar manic and bipolar psychoses with predominantly manic episodes. In the corresponding cases from schizophrenics hyper- and parakinetic basic syndromes were predominantly diagnosed. An evaluation of our preliminary results was undertaken in connection with our biochemical hypothesis on possible alterations in the regulation of Ca²⁺ concentrations and Ca²⁺-calmodulin-mediated processes under certain psychotic conditions.Our investigations were supported by the Ministerium für Hochund Fachschulwesen of the GDRParts of this paper were presented at the 5. Dresdner Symposion über Epilepsie und Antiepileptika, Dresden, November 1984. The authors wish to express their thanks to Prof. Emrich (Munich, FRG) for his assent and helpful discussions