| 中国宁夏回族人群15个人类短串联重复序列位点的遗传多态性研究 |
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| 引用本文： | 邓文国,何蕴韶,高建中,杨宝珍,马瑞霞,金仁晶,江梅华,王一鸣,曾瑞萍.中国宁夏回族人群15个人类短串联重复序列位点的遗传多态性研究[J].上海医学检验杂志,2005(6). |
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| 作者姓名： | 邓文国 何蕴韶 高建中 杨宝珍 马瑞霞 金仁晶 江梅华 王一鸣 曾瑞萍 |
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| 作者单位： | 中山大学医学遗传学教研室 广东广州510089
(邓文国，王一鸣)，中山大学达安基因诊断中心 广东广州510089
(何蕴韶，金仁晶，江梅华)，宁夏医学院附属医院耳鼻喉科 宁夏银川750004
(高建中，杨宝珍，马瑞霞)，中山大学医学遗传学教研室 广东广州510089(曾瑞萍) |
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| 摘 要： | 目的研究宁夏回族人群15个人类短串联重复序列位点(STR)D3S1358、THO1、D21S11、D18S51、vWA、CSF1PO、D8S1179、TPOX、FGA、D5S818、D13S317、D7S820、D16S539、D19S433、D2S1338的遗传多态性。方法通过STR复合扩增、基因扫描、基因分型调查了102名回族无关个体15个STR位点等位基因分布情况。结果15个STR位点均符合Hardy-W e inberg平衡,共检出150个STR等位基因,其频率分布在0.004 9~0.553 9之间,杂合度(H)为0.625 5~0.865 4,个体识别力(DP)为0.834 7~0.960 6,非父排除率(EPP)为0.381 2~0.720 4,多态信息含量(PIC)为0.572 2~0.845 6。结论此研究为进一步研究中国回族STR遗传结构奠定了基础,在人类学、法医学等领域也有重要的应用价值。
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| 关 键 词： | 短串联重复序列位点 遗传多态性 基因扫描 |
Polymorphisms of fifteen short tandem repeat loci in Ningxia Hui ethnic population |
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| DENG Wenguo,HE Yunshao,GAO Jiangzhong,YANG Baozhen,MA Ruixia,JIN Renjing,JIANG Meihua,WANG Yiming,ZENG Ruiping.Polymorphisms of fifteen short tandem repeat loci in Ningxia Hui ethnic population[J].Shanghai Journal of Medical Laboratory Sciences,2005(6). |
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| Authors: | DENG Wenguo HE Yunshao GAO Jiangzhong YANG Baozhen MA Ruixia JIN Renjing JIANG Meihua WANG Yiming ZENG Ruiping |
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| Institution: | DENG Wenguo,HE Yunshao,GAO Jiangzhong,YANG Baozhen,MA Ruixia,JIN Renjing,JIANG Meihua,WANG Yiming,ZENG Ruiping.Department of Medical Genetics,SUN Yat-sen University,Guangdong Guangzhou 510089,China |
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| Abstract: | Objective To investigate the genetic polymorphism of fifteen short tandem repeat(STR) loci(D3S1358,THO1,D21S11,D18S51,VWA,CSF1PO,D8S1179,TPOX,FGA,D5S818,D13S317,D7S820,D16S539,D19S433 and D2S1338) in Ningxia Hui ethnic population. Methods The allelic distributions of fifteen STR loci were generated through coamplification,genescan and genotype from 102 unrelated individuals.Results All the 15 loci met Hardy-Weinberg equilibrium.There were 150 STR alleles in Hui ethnic group,with its frequencies ranging from 0.004 9 to(0.553 9),heterozygosity(H) from 0.583 4 to 0.625 5,discrimination power(DP) from 0.834 7 to 0.960 6,probabilities of paternity exclusion(EPP) from(0.381 2) to 0.720 4,and polymorphic information content(PIC) from (0.572 2) to(0.845 6.) Conclusions The study provides a basis for the genetic structure of Chinese ethnic groups,and(also) is useful for its application to anthropology and forensic science. |
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| Keywords: | Short tandem repeat Genetic polymorphism Genescan |
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