甲状腺肿瘤患者血清中MBL和MASP-2的表达水平及其意义(英文)

Objective:The aim of the study was to detect the levels of mannose-binding lectin(MBL),MBL-associated serine protease 2(MASP-2) and explore the clinical significances of them in patients with primary thyroid neoplasms.Methods:By using ELISA method,we detected the serum levels of MBL and MASP-2 in 26 patients with papillary thyroid carcinoma(PTC),30 patients with thyroid adenoma(TA) and 26 healthy people,respectively.Results:Serum MBL level was(565.23 ± 76.70) μg/L in PTCs higher than(324.267 ± 24.74) μg/L in TAs,and(152.69 ± 16.95) μg/L in healthy of controlling group.There was statistical significance between PTC and TA(P < 0.05),however there was no difference between TA and healthy(P > 0.05).Serum MASP-2 level was(726.153 ± 78.88) μg/L in PTCs higher than(379.266 ± 30.26) μg/L in TAs,and(203.846 ± 29.09) μg/L in healthy.Serum MASP-2 level was higher in PTCs than TAs,and the difference had statistical significance(P < 0.01).But no difference was observed between in TAs and healthy.Conclusion:These findings might reflect inflammatory processes induced by defense mechanisms,in response to the development of the tumour.MBL may also be involved in the elimination of possible tumourigenic pathogens.

Expressions and clinical significances of mannose-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) in patients with thyroid neoplasm

Objective

The aim of the study was to detect the levels of mannose-binding lectin (MBL), MBL-associated serine protease 2 (MASP-2) and explore the clinical significances of them in patients with primary thyroid neoplasms.

Methods

By using ELISA method, we detected the serum levels of MBL and MASP-2 in 26 patients with papillary thyroid carcinoma (PTC), 30 patients with thyroid adenoma (TA) and 26 healthy people, respectively.

Results

Serum MBL level was (565.23 ± 76.70) μg/L in PTCs higher than (324.267 ± 24.74) μg/L in TAs, and (152.69 ± 16.95) μg/L in healthy of controlling group. There was statistical significance between PTC and TA (P < 0.05), however there was no difference between TA and healthy (P > 0.05). Serum MASP-2 level was (726.153 ± 78.88) μg/L in PTCs higher than (379.266 ± 30.26) μg/L in TAs, and (203.846 ± 29.09) μg/L in healthy. Serum MASP-2 level was higher in PTCs than TAs, and the difference had statistical significance (P < 0.01). But no difference was observed between in TAs and healthy.

Conclusion

These findings might reflect inflammatory processes induced by defense mechanisms, in response to the development of the tumour. MBL may also be involved in the elimination of possible tumourigenic pathogens.