Inhibition of normal and psoriatic epidermal phospholipase A2 by picomolar concentrations of recombinant human lipocortin I |
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| Authors: | P.H. CARTWRIGHT E. ILDERTON J.M. SOWDEN H.J. YARDLEY |
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| Affiliation: | Department of Dermatology, North Staffordshire Hospital Centre, Stoke-on-Trent, U.K. |
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| Abstract: | Normal human and psoriatic epidermal phospholipase A2 (PLA2) was inhibited by human recombinant lipocortin I when the substrate was present in a several million-fold molar excess. Inhibition was not total, even at relatively high concentrations of lipocortin I. It is therefore suggested that human epidermis contains two species of PLA2: one that is controlled by lipocortin I and one that is not. |
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