| IL-1和IL-4对肾小球系膜细胞p27和CDK2表达的影响 |
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| 引用本文： | 赵景宏,杨惠标,黄云剑,余荣杰. IL-1和IL-4对肾小球系膜细胞p27和CDK2表达的影响[J]. 解放军医学杂志, 2003, 28(9): 804-805 |
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| 作者姓名： | 赵景宏 杨惠标 黄云剑 余荣杰 |
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| 作者单位： | 400037,重庆,第三军医大学新桥医院;第三军医大学西南医院 |
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| 基金项目： | 国家自然科学基金资助课题(编号 30 1 0 0 0 83) |
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| 摘 要： | 探讨白细胞介素 1(IL 1)和白细胞介素 4 (IL 4 )对肾小球系膜细胞细胞周期调节蛋白 p2 7和周期素依赖性蛋白激酶CDK2表达的影响。利用体外培养的大鼠肾小球系膜细胞观察IL 1促进系膜细胞增生前后p2 7和CDK2 的表达变化 ,及同时应用IL 4后对上述表达变化的影响。结果发现 ,IL 1可以明显促进系膜细胞增生 ,同时观测到p2 7表达下降而CDK2 表达增高 ;IL 4可以抑制IL 1诱导的系膜细胞增生 ,同时发现p2 7表达增加而CDK2 表达减弱。提示IL 1和IL 4对系膜细胞增生的促进和抑制作用与细胞周期调节蛋白的表达变化密切相关。
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| 关 键 词： | 白细胞介素1 白细胞介素4 肾小球 基因产物 rex 细胞周期蛋白质依赖激酶类 |
| 修稿时间： | 2002-12-16 |
EFFECTS OF IL-1 AND IL-4 ON THE EXPRESSION OF p27 AND CDK2 IN RAT GLOMERULAR MESANGIAL CELLS IN VITRO |
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| Zhao Jinghong,Yang Huibiao,Huang Yunjian et al. EFFECTS OF IL-1 AND IL-4 ON THE EXPRESSION OF p27 AND CDK2 IN RAT GLOMERULAR MESANGIAL CELLS IN VITRO[J]. Medical Journal of Chinese People's Liberation Army, 2003, 28(9): 804-805 |
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| Authors: | Zhao Jinghong Yang Huibiao Huang Yunjian et al |
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| Affiliation: | Zhao Jinghong,Yang Huibiao,Huang Yunjian et al. Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China |
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| Abstract: | To evaluate the effects of interleukin-1 and interleukin-4 on the expression of p27 (one of the negative cell-cycle proteins) and CDK 2 (cell-cycle depending kinase, one of the positive cell-cycle proteins) on renal mesangial cells of rat in vitro, and to analyze their significance. The results showed that the proliferation of mesangial cells was induced markedly by interleukin-1, while the expression of p27 was down-regulated and that of CDK 2 was up-regulated. All of above changes were prevented by interleukin-4. The results suggested that the responses of rat renal mesangial cells to interleukin-1 and interleukin-4 were closely related to the changes in the expression of p27 and CDK 2. |
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| Keywords: | interleukin-1 interleukin-4 kidney glomerulus gene products rex cyclin-dependent kinases |
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