不同缺氧时间对大鼠肺循环改变的影响

为了解缺氧时间与肺动脉高压发生的关系，采用动物缺氧模型观察不同缺氧时间大鼠的肺血流动力学、右心室肥厚和肺血管结构等指标的变化。结果发现经缺氧处理后，大鼠肺动脉压于第３天开始升高，２周时达高峰；右心室重量在１周时明显增加；肺血管结构改变于３天时出现内皮细胞肿胀、变性，并逐渐发生细胞外基质增多，１周时出现管壁增厚，以缺氧３周最为明显。由此提示在３周以内，缺氧时间的长短与大鼠肺循环的改变程度具有明显的相关性。

Effect of Different Hypoxic Duration on Changes of Pulmonary Circulation

In order to assess the relationship between the hypoxic duration and pulmonary hypertension, we investigated the pulmonary hemodynamics and right ventricular hypertrophy and pulmonary vascular structure changes in rats with hypoxic exposure for 1 day to 3 weeks. After hypoxic treatment, the pulmonary artery pressure of rats increased in 3 days, and it was up to peak at 2 weeks later. The weight of right ventricle of rats significantly increased after 1 week. The endothelium of pulmonary vascular of rats became swollen in 3 days, and then increased in extracellular matrix deposition. Vessel wall thickening was found in 1 week hypoxic rats, and it was very significant in 3 week hypoxic rats. The results suggest that the duration of hypoxic treatment is related to the change of pulmonary circulation in 3 weeks in rats.