836例乳腺癌雌孕激素受体表达的临床分析

目的:探讨乳腺癌患者雌、孕激素受体状态分布及与临床指标的关系。方法:采用SP二步法对836例乳腺癌患者的术后肿瘤石蜡标本进行雌、孕激素受体检测,并与患者的年龄、月经情况、原发肿瘤病理类型和腋淋巴结转移状况相结合进行分析。结果:ER和PR的表达呈显著正相关(P<0.001);ER(+)、PR(+)、PR(-)表达率和年龄分布无关(P>0.05),≤39岁年龄组ER(-)表达率明显高于其他年龄组(P<0.001);绝经后ER(+)率高于绝经前患者(P<0.001),PR(+)率低于绝经前患者(P<0.001);组织病理学类型和ER、PR之间关系无显著性差异(P>0.05);无腋淋巴结转移患者的ER(+)、PR(+)表达率显著高于有转移者(P<0.001),ER(-)、PR(-)表达率低于有腋淋巴结转移者(P<0.001)。结论:乳腺癌患者ER、PR表达有一定规律,可作为制定综合治疗方案的依据,同时对判断预后有一定意义。

Clinical Analysis on Expression of Estrogen and Progesterone Receptors in Breast Cancer (A Report of 836 Cases )

Objective: To explore the distribution of estrogen receptor(ER) and progesterone receptor(PR) in breast cancer patients and compare the relationship between ER,PR and clinical parameters.Methods: 836 specimens of breast cancer were stained for ER and PR by SP two step method,and compared with age,menstuation status,histopathology and metastases of axillary lymph nodes in breast cancer patients.Results: The correlation between ER and PR was positive(P<0.001).The expression of ER(+),PR(+) and PR(-) were not associated with the age of patients(P>0.05).The ER negative expression in patients aged 39 or younger was significantly higher than other age groups(P<0.001).The ER(+) expression in postmenopausal patients were higher than that of the premenopausal ones(P<0.001),while the PR(+) expression was lower than that of the premenopausal patients(P<0.001).There was no significant difference between the histopathological type and the expression of ER and PR(P>0.05).The expression of ER(+) and PR(+) in patients without axillary lymph node metastasis were significantly higher than those in positive axillary lymph nodes ones(P<0.001),whereas the expression of ER(-) and PR(-) in patients without axillary lymphatic metastasis were lower than those in positive patients(P<0.001).Conclusion: The expression of ER and PR has certain regular patterns and may be as the marker to select the combining therapy and estimate the prognosis in breast cancer patients.