| 灯盏花素对脑缺血再灌注小鼠脑组织病理变化的影响 |
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| 引用本文： | 金玉楠,卢晓梅,张海鹏. 灯盏花素对脑缺血再灌注小鼠脑组织病理变化的影响[J]. 辽宁医学院学报, 2006, 27(4): 50-52 |
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| 作者姓名： | 金玉楠 卢晓梅 张海鹏 |
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| 作者单位： | 中国医科大学基础医学院病理生理教研室,辽宁,沈阳,110001;中国医科大学基础医学院病理生理教研室,辽宁,沈阳,110001;中国医科大学基础医学院病理生理教研室,辽宁,沈阳,110001 |
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| 摘 要： | 目的探讨灯盏花素对脑缺血再灌注小鼠脑组织病理变化的影响。方法复制小鼠脑缺血再灌注模型，并于术前15min腹腔注射灯盏花素注射液10mg／kg，于再灌注24h观察小鼠脑皮质血流，并取脑组织做石蜡切片，观察病理变化。结果缺血再灌注后脑皮质血流降低，病理切片反映脑细胞坏死严重；治疗后脑血流有所提高，脑细胞坏死减轻。结论灯盏花素能改善脑缺血再灌注小鼠脑皮质血流，减轻脑组织损伤。
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| 关 键 词： | 脑缺血再灌注 灯盏花素 |
| 文章编号： | 1000-5161(2006)04-0050-03 |
| 收稿时间： | 2006-03-19 |
| 修稿时间： | 2006-03-19 |
The Effect of Erigeron Breviscapus on Pathological Change in Brain Ischemia-reperfusion Mice |
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| JIN Yu-nan,LU Xiao-mei,ZHANG Hai-peng. The Effect of Erigeron Breviscapus on Pathological Change in Brain Ischemia-reperfusion Mice[J]. Journal of Liaoning Medical University (LNMU) Bimonthly, 2006, 27(4): 50-52 |
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| Authors: | JIN Yu-nan LU Xiao-mei ZHANG Hai-peng |
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| Affiliation: | Department of Pathophysiology, College of Basic Medical Sciences, China Medical University, Shenyang 110001 China |
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| Abstract: | Objective To investigate the effect of Erigeron breviscapus on pathological change in brain ischemia - reperfusion mice. Methods During the reperfusion period, Erigeron breviscapus injection was given 10mg/kg before operation by using cerebral IR models, the cerebral blood flow and pathologic study were determined. Results R group showed neron necrosis and capillary congest obviously, while the injury decreased in EB therpy group. Conclusions Erigeron breviscapus may decrease the IR injury in cerebral ischemia- reperfusion mice. |
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| Keywords: | brain ischemia reperfusion Erigeron breviscapus |
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