| 不同剂量阿托伐他汀对冠心病患者血脂及血清高敏C反应蛋白的影响 |
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| 引用本文： | 桑震池,陈书艳,李月华,王长谦,李毅刚.不同剂量阿托伐他汀对冠心病患者血脂及血清高敏C反应蛋白的影响[J].心脏杂志,2008,20(6):716-719. |
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| 作者姓名： | 桑震池 陈书艳 李月华 王长谦 李毅刚 |
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| 作者单位： | 上海交通大学医学院附属新华医院心内科,上海,200092 |
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| 摘 要： | 目的观察不同剂量阿托伐他汀在冠心病中国患病人群中降低血脂幅度、降低高敏C反应蛋白（hs-CRP）之间的差别,以及hs-CRP与血脂降低幅度之间的关联。方法连续入选128例冠心病患者,随机分为2组,一组服用阿托伐他汀10mg/d,另一组服用阿托伐他汀20mg/d,分别在入院24h内和服药后1月测定患者血脂、hs-CRP,比较两组和不同亚组患者不同剂量血脂、hs-CRP的变化。结果两组冠心病患者治疗1月后血清总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、载脂蛋白B（ApoB）、hs-CRP显著下降（均P<0.01）,hs-CRP变化值与血脂变化值无相关性,阿托伐他汀10mg/d组和20mg/d组相比,1月后血脂、hs-CRP变化值无统计学差异。结论冠心病患者无论是使用阿托伐他汀10mg/d还是20mg/d治疗1月,都能使血脂水平,包括TC、LDL-C、ApoB和炎症指标hs-CRP显著下降,同时阿托伐他汀的抗炎作用与降脂作用本身无相关性,但两剂量间并没有显著差异。
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| 关 键 词： | 阿托伐他汀 血脂 高敏C反应蛋白 |
Effect of different doses of atorvastatin on serum lipid and inflammatory factor hs-CRP in patients with coronary artery disease |
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| SANG Zhen-chi,CHEN Shu-yan,LI Yue-hua,WANG Chang-qian,LI Yi-gang.Effect of different doses of atorvastatin on serum lipid and inflammatory factor hs-CRP in patients with coronary artery disease[J].Chinese Heart Journal,2008,20(6):716-719. |
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| Authors: | SANG Zhen-chi CHEN Shu-yan LI Yue-hua WANG Chang-qian LI Yi-gang |
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| Institution: | SANG Zhen-chi,CHEN Shu-yan,LI Yue-hua,WANG Chang-qian,LI Yi-gang(Department of Cardiology,Xinhua Hospital,Shanghai 200092,China) |
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| Abstract: | AIM To investigate the effects of different doses of atorvastatin on serum levels of the blood lipid and high-sensitive C-reactive protein (hs-CRP) in Chinese patients with coronary artery disease and to study the relationship between hs-CRP and blood lipid. METHODS One hundred and twenty-eight consecutive patients with coronary artery disease were randomly divided into two groups. Patients in group A were given oral atorvastatin 10 mg once daily and patients in group B were given oral atorvastatin 20 mg on... |
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| Keywords: | atorvastatin blood lipid high-sensitive C-reactive protein |
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