| 藁本、辽藁本和新疆藁本挥发油化学成分分析及其血管活性观察 |
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| 引用本文： | 张迎春,陈畅,李韶菁,许海玉,李德凤,吴宏伟,杨洪军.藁本、辽藁本和新疆藁本挥发油化学成分分析及其血管活性观察[J].中国实验方剂学杂志,2011,17(14):159-165. |
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| 作者姓名： | 张迎春 陈畅 李韶菁 许海玉 李德凤 吴宏伟 杨洪军 |
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| 作者单位： | 中国中医科学院中药研究所,北京,100700 |
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| 基金项目： | 中国中医科学院自主选题课题 |
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| 摘 要： | 目的:分析比较藁本、辽藁本及代用品新疆藁本共7个样品中挥发油的化学成分,并观察对离体血管的舒张活性。方法:采用水蒸气蒸馏法提取7个藁本样品的挥发油,运用气相色谱-质谱法(GC-MS)对其化学成分进行分析鉴定,并用面积归一化法计算各成分相对含量;离体血管实验观察不同品种藁本挥发油对KCl预收缩大鼠胸主动脉环张力的影响。结果:从7个藁本样品中共鉴定出82个成分,其中含共有成分14个,各样品所鉴定成分平均占其总挥发油的94%。离体血管实验显示,各样品挥发油对大鼠胸主动脉环均有不同程度的舒张作用,且量效曲线呈非线性关系;半数有效量(ED50)30.4～400.1μg.mL-1。结论:不同品种藁本挥发油化学成分的种类及含量差异显著,对大鼠离体血管的舒张活性明显不同。
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| 关 键 词： | 藁本 新疆藁本 挥发油 气相色谱-质谱法 胸主动脉 离体血管 |
| 收稿时间： | 4/6/2011 12:00:00 AM |
Chemical Analysis and Observation on Vascular Activity of Essential Oil from Ligusticum sinensis, Conioselinum tataricum and Ligusticum jeholense |
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| ZHANG Ying-chun,CHEN Chang,LI Shao-jing,XU Hai-yu,LI De-feng,WU Hong-wei and YANG Hong-jun.Chemical Analysis and Observation on Vascular Activity of Essential Oil from Ligusticum sinensis, Conioselinum tataricum and Ligusticum jeholense[J].China Journal of Experimental Traditional Medical Formulae,2011,17(14):159-165. |
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| Authors: | ZHANG Ying-chun CHEN Chang LI Shao-jing XU Hai-yu LI De-feng WU Hong-wei and YANG Hong-jun |
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| Institution: | Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China |
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| Abstract: | |
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| Keywords: | Ligusticum sinensis Conioselinum tataricum volatile oil GC-MS thoracicaorta vascular activity |
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