钩藤对吗啡诱导的大鼠条件性位置偏爱效应的影响

目的:观察钩藤提取液对吗啡诱导的大鼠条件性位置偏爱效应的影响。方法:SD雄性大鼠,取经过基线测定合格的40只大鼠,随机分为空白对照组、吗啡模型组(15 mg.kg-1,sc)、钩藤提取液低剂量(3 g.kg-1,ig)+吗啡组、钩藤提取液高剂量(9 g.kg-1,ig)+吗啡组,每组10只动物,给药5 d。采用倾向性程序训练大鼠,建立位置偏爱模型,观察钩藤提取液对大鼠在伴药箱(白箱)逗留时间的影响。结果:吗啡模型组训练5 d后,大鼠在白箱的逗留时间明显延长(与空白对照组比较,P<0.01),说明经过5 d训练,大鼠对吗啡形成了位置偏爱。给予钩藤提取液高剂量组(9 g.kg-1)能显著缩短大鼠在白箱的逗留时间(与模型组比较,P<0.05)。结论:钩藤提取液能够抑制吗啡诱导的条件性位置偏爱效应的形成,具有一定的抗药物精神依赖作用。

Effect of Uncariae Ramulus Cum Uncis on Conditioned Place Preference Induced by Morphine in Rats

Objective: To observe the effects of Uncariae Ramulus Cum Uncis on the conditioned place preference (CPP) induced by morphine in rats. Method : Conditioned place preference was established by morphine sc 15 mg ·kg^-1 ·d^-1 for 5 d. In the training time,two Uncariae Ramulus Cum Uncis groups (3,9 g ·kg^-1,ig) were given Ramulus Uncariae cum Uncis after sc morphine 12 h later daily. The duration of staying in the White Compartment was recorded. Result : The 3 g ·kg^-1 group could not influence morphine-dependent CPP; the 9 g ·kg^-1 group could extinct to some extent morphine-dependent CPP. Conclusion : The result suggest that Uncariae Ramulus Cum Uncis could extinct to some extent morphine-dependent CPP and has the function of resisting psychological dependence.