| 剂型因素和给药途径对人参皂苷Rg1 在大鼠 血清和脑组织中分布的影响 |
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| 引用本文： | 陈新梅. 剂型因素和给药途径对人参皂苷Rg1 在大鼠 血清和脑组织中分布的影响[J]. 中国实验方剂学杂志, 2011, 17(14): 43-46 |
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| 作者姓名： | 陈新梅 |
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| 作者单位： | 山东中医药大学药学院,济南,250355 |
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| 摘 要： | 目的:考察剂型因素和给药途径对人参皂苷Rg1(GRg1)在大鼠血清和脑组织中分布的影响。方法:大鼠鼻腔给GRg1鼻腔喷雾剂,以大鼠口服和鼻腔给GRg1生理盐水为对照,给药后测定各组大鼠脑和血清中的GRg1的含量。采用Wagner-Nelson法处理数据。结果:鼻腔给药途径使GRg1在血清和脑组织中的分布和转运效率分别提高了5.05,2.50倍;喷雾剂的剂型因素使GRg1在血清和脑组织中的吸收和转运效率分别提高了11.80,3.35倍。结论:GRg1鼻腔给药途径和喷雾剂都能显著提高其生物利用度。
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| 关 键 词： | 人参皂苷Rg1 鼻腔给药 喷雾剂 |
| 收稿时间： | 2010-12-03 |
| 修稿时间： | 2010-12-21 |
Effect of Dosage Form and Administration Route to Distribution of Ginsenoside Rg1 in Serum and Brain of Rats |
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| CHEN Xin-mei. Effect of Dosage Form and Administration Route to Distribution of Ginsenoside Rg1 in Serum and Brain of Rats[J]. China Journal of Experimental Traditional Medical Formulae, 2011, 17(14): 43-46 |
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| Authors: | CHEN Xin-mei |
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| Affiliation: | Shan Dong Traditional Chinese Medical University |
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| Abstract: | Objective: To discuss the effect of dosage form and administration route to the distribution of ginsenoside Rg1 in serum and brain of the rats. Methods: Compared with ginsenoside Rg1 saline solution administrated from nasal route and oral route, ginsenoside Rg1 nasal spray was administrated from nasal route in rats. The concentration of ginsenoside Rg1 in the serum and brain was detected by HPLC-UV. The data was analysised by the Wagner-Nelson method. Results: The distribution and transport efficiency of ginsenoside Rg1 was improved 5.05 and 2.50 times respectively by nasal administration route. The distribution and transport efficiency of ginsenoside Rg1 was improved 11.80 and 3.35 times respectively by nasal spray. Conclusion: The bio-availability of ginsenoside Rg1 can be improved dramatically by the nasal administration route and nasal spray. |
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| Keywords: | ginsenoside Rg1 nasal administration spray |
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