原花青素柔性纳米脂质体小鼠皮肤局部药代动力学

目的:制备原花青素柔性纳米脂质体,考察原花青素在小鼠腹部皮肤的滞留量与时间的关系及其局部经皮给药的药动学,探讨柔性纳米脂质体促进药物的经皮吸收的作用。方法:采用薄膜分散法制备原花青素柔性纳米脂质体,紫外-可见分光光度法测定不同时间给药皮肤中原花青素生物滞留量,DAS软件拟合药物动力学参数。结果:原花青素柔性纳米脂质体包封率为(72.52±8.63)%,平均粒径167.5 nm,Zeta电位-60.3,多分散指数0.309;在小鼠皮肤中滞留量的动力学过程符合二室模型。结论:原花青素柔性纳米脂质体中有效成分能较快渗透进入皮肤,并在皮肤局部较长时间蓄积。

Dermatopharmacokinetic Studies of Proanthocyanidins Flexible Nanoliposomes in Rat Topical Skin

Objective: Flexible nanoliposomes was prepared with proanthocyanidins to study the relationship between deposition and time of proanthocyanidins in rats'abdominal skin and its topical pharmacokinetics. The function of flexible nanoliposomes in enhancing the transdermal absorption of the encapsulated drug was investigated. Method : Flexible nanoliposomes was prepared with proanthocyanidins using a film dispersion method to determine the relationship between deposition and time of proanthocyanidins in rats' abdominal skin by ultraviolet spectrophotometry, and the pharmacokinetic parameters were fitted by DAS. Result : Depositions of different time in rats' abdominal skin could be fitted with the two compartment model. Conclusion : The active ingredients of proanthocyanidins flexible nanoliposomes can permeate through the skin effectively and lie long time.