中度高原地区慢性胃炎的病理特点及因素的分析

目的：分析西宁地区及周边八县(海拔2000m-2500m)慢性胃炎发病特点及高原低氧对胃粘膜的损害作用。方法：选取65例我院胃镜室行胃镜检查的CG病人及活组织送病理学检查，分析内镜诊断和病理学诊断，并以问卷形式调查其生活状况资料。结果：内镜诊断CSG43例，绝大部分病理学诊断为CAG(76．74％)，其中近一半伴有肠上皮化生、不典型增生及淋巴滤泡形成等癌前病变；内镜诊断CAG21例，病理学诊断绝大部分为较重的CAG，且伴有较重的上述病变。结论：青海地区慢性胃炎较重，可能与高原低氧环境下一氧化氮(NO)水平降低和内皮素(ET)水平增高，影响胃粘膜微循环血流量有关。

The Feature of Pathology of Chronic Gastritis and Relative Factors in Plateau

Objective:To analyze the feature of chronic gastritis in Qinhai plateau and the harmful effect of plateau hypoxia on gastric mucosa. Methods: We selected the cases of chronic gastritis (CG) in the endoscopic room in Qinhai Province People's Hospital in some time, and examined the gastric tissue that was taken by endoscopy. The endoscopic and pathologic diagnosis was analyzed while we investigated these patients' living condition by questionnaire.Results:Chronic superficial gastritis (CSG) was 43 by endoscopy. The most of these cases' pathologic diagnosis were chronic atrophic gastritis (CAG) (76.74%). There were about half of them companying others pathology, such as intestinal change, untypical proliferate and lymphadenia. CAG were 21 by endoscopy. The most of these cases' pathologic diagnosis were severe CAG and companying serious pathology above-mentioned. Conclusion: The chronic gastritis is serious in the district of Qinhai. The relation between the lower NO and the higher ET, which affected the blood of gastric mucosa tiny circulation was the possible reason.