A GIRL WITH RECURRENT INFECTIONS, LOW IgM AND AN ABNORMAL CHROMOSOME NUMBER 1

A girl, now 3 years of age, is described, who since the age of 3 months had many, often severe, infections mainly caused by microorganisms with a polysaccharide structure. In addition she had very low IgM and no iso-agglutinins in her serum, and furthermore we were able to show an abnormal chromosome number 1 in more than 80% of the cells investigated from peripheral blood. The possibility that antibodies to polysaccharide antigens are directed from chromosome number 1 is referred to in this paper.