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The regulation of galanin gene expression in gonadotropin-releasing hormone neurons |
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| Authors: | Patricia D. Finn Donald K. Clifton Robert A. Steiner |
| Affiliation: | aDepartments of Physiology and Biophysics, Box 357290, University of Washington, Seattle, Washington 98195, USA bDepartment of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98195, USA cPopulation Center for Research in Reproduction, University of Washington, Seattle, Washington 98195, USA |
| Abstract: | In rats, galanin modulates luteinizing hormone (LH) secretion, and gonadotropin-releasing hormone (GnRH) neurons provide a possible source of this galanin. To understand galanin's physiological role in GnRH neurons, we used double-label in situ hybridization and computerized image analysis to examine the regulation of galanin message in GnRH neurons. We found that galanin gene expression in GnRH neurons is regulated by sex steroids, induced coincident with the LH surge, and persists well after the completion of the LH surge, and that the induction of galanin message in GnRH neurons coincident with the LH surge is sexually differentiated neonatally. We postulate that the rise in galanin gene expression in GnRH neurons at the time of the LH surge serves to replenish galanin released with GnRH that is needed for the production of the LH surge, or that galanin is involved in physiological events that occur subsequent to the LH surge. |
| Keywords: | Gene expression Sex steroids Luteinizing hormone LH surge |
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