Association of a vascular endothelial growth factor gene 936 C/T polymorphism with breast cancer risk: a meta-analysis |
| |
| Authors: | Dae Sik Yang Kyong Hwa Park Ok Hee Woo Sang Uk Woo Ae-Ree Kim Eun Sook Lee Jae-Bok Lee Yeul Hong Kim Jun Suk Kim Jae Hong Seo |
| |
| Affiliation: | (1) Department of Radiation Oncology, Korea University Guro Hospital, 97 Gurodong-Gil Guro-Ku, Seoul, Korea;(2) Division of Medical Oncology, Department of Internal Medicine, Korea University Guro Hospital, 97 Gurodong-Gil Guro-Ku, Seoul, Korea;(3) Department of Diagnostic Radiology, Korea University Guro Hospital, 97 Gurodong-Gil Guro-Ku, Seoul, Korea;(4) Department of Surgery, Korea University Guro Hospital, 97 Gurodong-Gil Guro-Ku, Seoul, Korea;(5) Department of Pathology, Korea University Guro Hospital, 97 Gurodong-Gil Guro-Ku, Seoul, Korea |
| |
| Abstract: | Published studies on the association between the vascular endothelial growth factor (VEGF) gene 936 C/T polymorphism and breast cancer risk are inconclusive, and a meta-analysis is required to verify the association. Nine studies, including a total of 4,973 cases and 5,035 controls, were subjected to meta-analysis. When all eligible subjects were pooled for meta-analysis, the CT + TT genotypes were not associated with a significant decrease in breast cancer risk (odds ratio = 0.87; 95% confidence interval 0.75–1.02; P = 0.087). We also categorized by ethnicity (Caucasian, Asian, or mixed) for subgroup analysis, however, according to this subgroup analysis, we found no significant association between the CT and TT versus CC genotype with breast cancer risk reduction in any of the subgroups. We conclude that the VEGF gene 936 C/T polymorphism does not affect breast cancer risk. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
