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NF-κB和EGFR在不同放射敏感性胶质瘤中的表达
引用本文:陶胜忠,艾文兵,易伟,万锋,雷霆,薛德麟. NF-κB和EGFR在不同放射敏感性胶质瘤中的表达[J]. 肿瘤防治研究, 2005, 32(5): 257-259
作者姓名:陶胜忠  艾文兵  易伟  万锋  雷霆  薛德麟
作者单位:4300030,武汉,华中科技大学同济医学院附属同济医院神经外科
摘    要: 目的 探讨NF-κB和EGFR的表达水平与胶质瘤放射敏感性的关系。方法 应用免疫组织化学SABC法检测NF-κB p50、p65及EGFR在5例正常脑组织和82例不同放射敏感性胶质瘤中的表达。结果 NF-κBB p50、p65和EGFR在正常脑组织中均未见表达。髓母细胞瘤、室管膜瘤、少枝胶质细胞瘤、低(Ⅰ~Ⅱ级)及高级别(Ⅲ~Ⅳ级)星形细胞瘤、多形性胶质母细胞瘤的NF-κB和EGFR表达率呈依次上升趋势。对放疗最敏感的髓母细胞瘤表达率与其他各组均有显著性差异(P<0.05)。结论 NF-κB和EGFR表达水平与胶质瘤的不同放射敏感性可能相关。

关 键 词:胶质瘤  放射敏感性  EGFR  NF-κB
文章编号:1000-8578(2005)05-0257-03
收稿时间:2004-07-07
修稿时间:2004-11-24

The Expression of NF-κB and EGFR in Gliomas with Differently Radiosensitivity
TAO Sheng-zhong,AI Wen-bing,YI Wei,Wan Feng,LEI Ting,XUE De-lin. The Expression of NF-κB and EGFR in Gliomas with Differently Radiosensitivity[J]. Cancer Research on Prevention and Treatment, 2005, 32(5): 257-259
Authors:TAO Sheng-zhong  AI Wen-bing  YI Wei  Wan Feng  LEI Ting  XUE De-lin
Affiliation:Department of Neurosurgery , Tongji Hospital , Tongji Medical College , Huazhong University of Science and Technology , Wuhan 430030 , China
Abstract:Objective  To investigate the relationship between the expression of NF-κB and Epidermal Growth Factor Receptor and radiosensitivity in human gliomas. Methods  The expression of NF-κB and EGFR in 82 cases of gliomas and 5 cases of normal brain tissues were studied by immunohistochemical method of SABC. Results  None of the normal tissue exhibited NF-κB and EGFR. The expression both NF-κB and EGFR was significantly increased in ascending order from medulloblastoma , ependymoma , oligodendroglioma , low and high grade astrocytoma ,and glioblastoma multiforme. Conclusion  The positive expression rate of NF-κB and EGFR proteins were correlated with radiosensitivity of gliomas. They might serve as indicator of radiosensitivity in human gliomas.
Keywords:EGFR
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