| 胆道梗阻时脱氧胆酸钠及乳果糖对小肠粘膜的影响 |
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| 引用本文： | 王喜艳,平小佳.胆道梗阻时脱氧胆酸钠及乳果糖对小肠粘膜的影响[J].中国普外基础与临床杂志,1998,5(2):80-81. |
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| 作者姓名： | 王喜艳 平小佳 |
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| 作者单位： | 新疆医学院第一附属医院 |
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| 摘 要： | 为观察外源性胆盐及乳果糖对小肠粘膜的影响，将２０只成年Ｗｉｓｔａｒ大鼠随机分为假手术组、胆管结扎组、胆管结扎＋胆盐治疗组和胆管结扎＋乳果糖治疗组，每组５只，２１天后处死动物，观察小肠粘膜的病理及四种酶活性的改变。结果：胆管结扎组小肠粘膜明显水肿，ＡＴＰａｓｅ、ＳＤＨ、ＡＫＰ活性明显减弱，Ａｃｐ活性明显增强；脱氧胆酸钠及乳果糖治疗组小肠粘膜未见异常或见轻度水肿，四种酶活性均较胆管结扎组有明显改善。提示，外源性胆盐及乳果糖对梗阻性黄疸时的小肠粘膜有保护作用。
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| 关 键 词： | 梗阻性黄疸 小肠粘膜 脱氧胆酸钠 乳果糖 |
PROTECTIVE EFFECT OF SODIUM DEOXYCHOLATE AND LACTULOSE ON OBSTRUCTIVE JAUNDICED INTESTINAL MUCOSA |
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| Wang Xiyan,Ping Xiaojia.PROTECTIVE EFFECT OF SODIUM DEOXYCHOLATE AND LACTULOSE ON OBSTRUCTIVE JAUNDICED INTESTINAL MUCOSA[J].Chinese Journal of Bases and Clinics In General Surgery,1998,5(2):80-81. |
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| Authors: | Wang Xiyan Ping Xiaojia |
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| Institution: | Wang Xiyan,Ping Xiaojia. Department of General Surgery,First Affiliated Hospital,Xinjiang medical College,Wulumuqi 830000 |
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| Abstract: | This experimental study was aimed at observing the influence of bile salt and lactulose on intestinal mucosa of obstructive jaundiced rat. Twenty adult Wistar rate were divided into four groups (five rats for each group): sham operation, common bile duct ligation (CBDL), CBDL plus sodium deoxycholate feeding and CBDL plus lactulose feeding. The results showed that the intestinal mucosa of rats with obstructive jaundice took on marked edema, markedly decreased activities of adenosine triphosphatase, alkaline phosphatase and succinic dehydrogenase and intensified acid phosphatase activity. However, the intestinal mucosa of the rats, treated with bile salt or lactulose as compared with that of the obstructive jaundiced rats showed both pathological and histochemical improvement. |
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| Keywords: | Obstructive jaundice Intestinal mucosa Sodium deoxycholate Lactulose |
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