| 噻磺隆原药的致突变性研究 |
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| 引用本文： | 冯学庆,叶林,王维,朱建华,王安莲,王秋萍,鲍军辉. 噻磺隆原药的致突变性研究[J]. 癌变．畸变．突变, 2003, 15(3): 180-182. DOI: 10.3969/j.issn.1004-616x.2003.03.017 |
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| 作者姓名： | 冯学庆 叶林 王维 朱建华 王安莲 王秋萍 鲍军辉 |
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| 作者单位： | 安徽省职业病防治研究所，安徽 合肥 230022 |
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| 摘 要： | 目的：研究噻磺隆原药是否具有潜在的遗传危害，为其使用安全性提供依据。方法：利用Ames试验、微核试验、小鼠睾丸精母细胞染色体畸变试验对噻磺隆原药的致突变性进行研究。结果：无论加或不加S9条件下，各剂量组对TA97、TA98、TA100和TA102菌株均无诱发回复突变菌落数增加作用；以1 000、2 500和5 000 mg/kg的噻磺隆原药对小鼠骨髓嗜多染红细胞的微核细胞率无增加作用；噻磺隆原药各剂量组染色体畸变细胞率与阴性对照组比较差别无显著性(P > 0.05)。结论：噻磺隆原药对Ames试验、微核试验、染色体畸变试验结果表明，在本实验条件下，噻磺隆原药无致突变作用。
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| 关 键 词： | 噻磺隆 Ames试验 染色体畸变 微核 突变 |
| 文章编号： | 1004-616X(2003)03-0180-03 |
| 收稿时间： | 2002-12-30 |
| 修稿时间： | 2002-12-30 |
STUDY ON MUTAGENICITY OF THIFENSULFURON |
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| FENG Xue-qing,YE Lin,WANG Wei,et al. STUDY ON MUTAGENICITY OF THIFENSULFURON[J]. Carcinogenesis,Teratogenesis and Mutagenesis, 2003, 15(3): 180-182. DOI: 10.3969/j.issn.1004-616x.2003.03.017 |
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| Authors: | FENG Xue-qing YE Lin WANG Wei et al |
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| Affiliation: | Anhui Institute of Occupational Health, Hefei 230022,China |
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| Abstract: | Purpose:To explore potential mutagenicity of thifensulf ur on. Methods: The potential mutagenicity of thifensulfuron was s tudied by Ames test, micronucleus test of polychromatic erythro cytes in bone marrow and chromosomal aberration test of sperma tocytes in mice to provide the data for its safety. Res ults: No increase in the number of revertant colonies was found in the Ames test in all dosage groups. The results were also negative in the chromosomal aberration test of spermatocytes in mice and in the micronucleus test at dose s from 1 000 to 5 000 mg/kg. Conclusion: The mutagenicity of thifensalfuron was not showed in this study. |
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| Keywords: | thifensulfuron Ames test chromosome aberration micronuc leus mutagenesis. |
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