THE RELATIONSHIPS BETWEEN PLASMA CHOLESTEROL、TRIGLYCERIDE、HIGH DENSITY LIPOPROTEIN AND ION TRANSPORT ENZYMES IN ERYTHROCYTE MEMBRANES

Objective To investigate the relationships between levels of plasma cholesterol (Ch), triglyceride (TG)、high density lipoprotein(HDL) and ion transport enzyme activities in red cell membranes of essential hypertensive patients.Methods Plasma Ch, TG, HDL-c, activites of Na~ -K~ -ATPase and Ca~(2 )-ATPase, Ca~(2 )-binding capacity of interior membrane surface, and membrane Ch, phospholipid(PL) were measured in 32 normotensive (NT) subjects and 55 essential hypertensive patients(HT).Results ①Mean artery pressure(MAP), plasma Ch、TG and membrane Ch levels, and membrane cholesterol/phospholipid(C/P) molar ratio were significantly increased compared with those in NT group, respectively; ②The plasma HDL-c level, the activities of Na~ -K~ -ATPase and Ca~(2 )-ATPase, and the Ca~(2 )-binding capacity of the interior membrane surface in HT group were significantly lower than those in NT group, respectively.Conclusion The depressed activities of Na~ -K~ -ATPase and Ca~(2 )-ATPase, and Ca~(2 )-binding capacity of the interior surface in cell membranes are the major evidence of ion transport abnormalities in essential hypertension. The plasma TG and membrance C/P molar ratio-dependent changes in membrane microviscosity seem to be responsible for the modulation of particular ion transport pathways.