| 糖尿病肾病与血浆内皮素1及C反应蛋白的相关性研究 |
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| 引用本文： | 黄雯,冯维华.糖尿病肾病与血浆内皮素1及C反应蛋白的相关性研究[J].中华糖尿病杂志,2009,17(11):842-843. |
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| 作者姓名： | 黄雯 冯维华 |
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| 作者单位： | 山东大学附属千佛山医院,济南,250014 |
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| 摘 要： | 目的探讨糖尿病肾病（DN）与血浆内皮素1（ET-1）、C反应蛋白（C-RP）的关系。方法测定86例T2DM患者（DM组）和30例健康对照者（NC组）血压、血糖、血脂、SCr、ET-1、C-RP和尿白蛋白排泄率（UAER）。结果血浆ET-1和C-RP在DM组较NC组显著升高（P〈0．05，P〈0．01），且DM组血浆ET-1和C-RP水平随着SCr、UAER的增加而升高（P〈0．05，P〈0．01）。结论血浆ET-1和C-RP可能参与DN的发生、发展。
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| 关 键 词： | 糖尿病肾病 内皮素1 C反应蛋白 |
Study of correlation of diabetic nephropathy with serum endothelin(ET-1) and C-reactive protein(CRP) |
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| HUANG Wen,FENG Wei-hua.Study of correlation of diabetic nephropathy with serum endothelin(ET-1) and C-reactive protein(CRP)[J].CHINESE JOURNAL OF DIABETES MELLITUS,2009,17(11):842-843. |
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| Authors: | HUANG Wen FENG Wei-hua |
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| Institution: | ( Qian foshan Hospital of Shandong University , Jinan 250014 ,China) |
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| Abstract: | Objective To investigate the relationship of diabetic nephropathy with serum endothelin- 1（ET-1） and C-reactive protein（CRP）. Methods Levels of blood pressure, glucose, lipid, creatinine, ET-1 ,CRP and urinary albumin excretion（UAER） were measured and calculated in 86 patients with type 2 diabetes mellitus （T2DM）and 30 healthy subjects. Results Serum ET-1 and CRP were significantly higher in T2DM than in control（P〈0.05, P〈0. 01）. Serum ET-1 and CRP were increased with increment of serum creatinine and UAER （P 〈 0. 05, P 〈 0. 01 ）. Conclusions Serum ET-1 and CRP may be involved in the development and progression of diabetic nephropathy. |
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| Keywords: | Diabetic nephropathy Endothelin-1 C-reactive protein |
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