| 粉尘螨变应原多聚体及其变应原性 |
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| 引用本文： | 张鲁雁,江世益,陈刚.粉尘螨变应原多聚体及其变应原性[J].复旦学报(医学版),2004,31(2):206-207,217. |
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| 作者姓名： | 张鲁雁 江世益 陈刚 |
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| 作者单位： | 复旦大学化学系基础化学实验中心,上海,200032 |
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| 摘 要： | 目的 制备粉尘螨变应原多聚体(PDF)。方法用戊二醛与粉尘螨浸液(Df)反应制成PDf，通过凝胶层析分析其稳定性，并用皮肤点制试验测定其变应原性。结果 获得相对分子质量在600000范围内的PDf，并具有低变应原性，且在2年内相当稳定。结论 制成的。PDf可用于临床免疫治疗，它具有安全性、稳定性和有效性。
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| 关 键 词： | 粉尘螨 变应原多聚体 变应原性 免疫治疗 |
| 修稿时间： | 2003年6月2日 |
Polymerized Allergen and Allergenicity of Dermatophagoides farinae |
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| ZHANG Lu-yan,JIANG Shi-yi,CHEN Gang.Polymerized Allergen and Allergenicity of Dermatophagoides farinae[J].Fudan University Journal of Medical Sciences,2004,31(2):206-207,217. |
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| Authors: | ZHANG Lu-yan JIANG Shi-yi CHEN Gang |
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| Abstract: | Purpose To preparing the polymerized allergen (PDf) from Dermatophagoides farinae (Df). Methods The extract of Df was treated with glutaraldehyde and formed PDf,detected the stability and the allergenicity using gel chromatography and skin prick test. Results The PDf was obtained,the molecular weight of that was 600 000 and the allergenicity of PDf was decreased when compared with the untreated extract from Df.PDf was more stable within 2 years. Conclusions The PDf might be safe,stability and effectve antigens for immunotherapy in clinical use. |
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| Keywords: | Dermatophagoides farinae allergenicity polymer |
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