糖尿病合并冠状动脉粥样硬化性心脏病治疗研究进展

糖尿病患者常常合并心血管疾病。糖尿病易并发冠状动脉粥样硬化性心脏病(CAD)的原因复杂,主要包括高血压、高血脂、内皮功能紊乱、血小板异常、高凝状态、糖基化终末产物生成增多、慢性全身性低度炎症状态和氧化应激等。糖尿病合并CAD具有冠状动脉病变弥漫,狭窄程度重的特点。治疗有非药物治疗、药物治疗和血运重建治疗,其中药物治疗主要有降糖、降压、降脂、抗血小板以及并发急性ST段抬高心肌梗死时静脉溶栓治疗,血运重建治疗包括经皮冠状动脉介入术和冠状动脉旁路搭桥术。本文就糖尿病合并CAD的治疗研究进展予以综述。

Progress in Diabetic Patients with Coronary Heart Disease

Diabetes significantly increases the risk of cardiovascular disease. Many diabetics developed hypertension, high blood lipid, endothelial dysfunction, platelet abnormalities, hypercoagulative state, generate more glycosylation end products and chronic systemic low-level inflammation and oxidative stress. Diabetic patients with coronary heart disease are characteristic of diffuse coronary artery disease and narrow serious. Treatment of diabetic patients with coronary heart disease includes controlling glucose, blood tension, suppressing the glycemic level, lipid level, and inhibiting thrombocytic aggregation. Patients with acute ST-elevation myocardial infarction need to be treated with revascularization, including percutaneous coronary intervention and coronary artery bypass surgery. This paper reviewed research progress in treating diabetic patients with coronary heart disease.