应用重组人G-CSF联合EPO治疗MDS疗效观察

为了观察应用重组人粒细胞集落刺激因子(G-CSF)联合重组人红细胞生成素(EPO)治疗骨髓增生异常综合征(MDS)的疗效,观察15例MDS患者应用GCSF联合EPO治疗后的血像和骨髓像及临床表现的变化,并了解其疗效。给患者GCSF300μg/d。联合EPO100U/(kg·d),连续10天,皮下注射。结果表明:15例MDS患者10例粒系明显改善,7例红系改善,输血间隔延长;患者对联合应用药物的副作用均能耐受。结论:应用重组人G-CSF联合EPO治疗MDS是一种有效治疗方法,能改善临床表现、减少感染和出血,有利临床缓解。

Effect of Recombinant Human G-CSF Combined with EPO in Treatment of Patienfs with MDS

To investigate the efficaciousness of recombinant human granulocyte colony-stimulating factor (G-CSF) combined with recombinant human erythropoietin (EPO) in the treatment of patients with myelodysplastic syndrome (MDS), the hematological changes in the blood and bone marrow along with clinical features after treatment with G-CSF and EPO in 15 patients were observed. Patients were subcutaneously injected with G-CSF 300 microg/d for 10 days, then injected with EPO 100 U/(kg x d) for 10 days. The results showed that the obvious improvements in granulocytes of blood were found in 10 patients with MDS, improvements in erythrocytes of blood were observed in 7 patients with MDS. No serious side effects occured is all treated patients. In conclusion, treatment of G-CSF in combination with EPO is effective for patients with MDS.