2,3,7,8-Tetrachlorodibenzo-p-dioxin toxic effects and tissue levels in animals from the contaminated area of seveso,Italy |
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| Authors: | R. Fanelli M. P. Bertoni M. G. Castelli C. Chiabrando G. P. Martelli A. Noseda S. Garattini C. Binaghi V. Marazza F. Pezza |
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| Affiliation: | (1) Laboratory of Environmental Pharmacology and Toxicology, Mario Negri Institute for Pharmacological Research, Milano, Italy;(2) Istituto Zooprofilattico Sperimentale della Lombardia e dell 'Emilia, Milano, Italy;(3) Veterinary Service of the Regione Lombardia, Milano, Italy;(4) Istituto di Ricerche Farmacologiche, !["ldquo"]("/content/rg09547877175506/xlarge8220.gif") Mario Negri!["rdquo"]("/content/rg09547877175506/xlarge8221.gif") , Via Eritrea 62, 20157 Milano, Italy |
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| Abstract: | After the environmental contamination by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the area of Seveso, Italy, thousands of small domestic animals (mainly rabbits and poultry) died within a few weeks. Autopsies on dead animals showed various pathological signs, such as hepatic lesions and haemorrhage. TCDD was monitored in animal tissues by gas chromatography-mass fragmentography; rabbit liver levels corresponded fairly well to soil contamination, which indicated that this species can be used as a tool for tracking the presence of TCDD in the environment. |
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