Characterization of a tissue kallikrein in human prolactin-secreting adenomas |
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| Authors: | T H Jones C D Figueroa C Smith D R Cullen K D Bhoola |
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| Affiliation: | University Department of Medicine, Northern General Hospital, Sheffield. |
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| Abstract: | Immunoreactive tissue kallikrein was co-localized with prolactin in all the eleven prolactin-secreting adenomas of the human anterior pituitary gland examined in this study. The intracellular distribution of immunoreactivity in the prolactin-secreting cells suggests that tissue kallikrein is located within the Golgi complex of these cells. Both the intracellular hormone-processing action and the kininogenase activity of tissue kallikrein may be of functional importance in human prolactinomas. |
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