正常高值血压与尿微量白蛋白的关系

目的探讨尿微量白蛋白含量与血压水平的相关性。方法根据《2004年中国高血压防治指南》选择正常高值血压者（≥120／80mmHg）109例及正常血压者（〈120／80m／nHg）49例，测量血压，计算体重指数（BMI），测定空腹血糖（VBS）、血清总胆固醇（CHO）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL—C）、低密度脂蛋白胆固醇（LDL—C）、尿微量白蛋白（EusA法）等，并做比较。结果正常高值血压组与正常血压组相比，尿微量白蛋白含量升高（3．08±1．58）mg／L比（3．86±1．7）mg／L，P〈0．01]，CHO、TG、HDL—C和LDL—C两组差异无统计学意义（P〉0．05）。Spearman相关分析显示，尿微量白蛋白与血压、血糖呈正相关，相关系数收缩压r=0．177，P〈0．05；舒张压r=0．252，P=0．001；空腹血糖r=0．279，P〈0．01。校正年龄、性别、血脂、体重指数偏相关分析表明，尿微量白蛋白含量与血压、血糖水平仍呈正相关，相关系数收缩压r=0．156，P=0．055；舒张压r=0．233，P〈0．05；空腹血糖r=0．251，P〈0．05。结论①正常高值血压组尿微量自蛋白水平较高，血糖、体重指数有异常变化，但血脂无异常变化。②尿微量白蛋白发生与舒张压、血糖关系更密切。

Associontion of high-normal blood pressure with microalbuminuria

Objective This study was performed to investigate the relationship between blood pressure and microalbuminuria. Methods According to 2004 guideline for the preventing and treating hypertension of china, 109 high-normal blood pressure individuals （≥120 or 80 mm Hg） and 49 normal blood pressure individuals （〈120/80 mm Hg） were selected from the people who are fit for the critia. The blood pressure, body mass index （ BMI ）, fasting blood glucose （FBS）, total cholesterol（ CHO ）, triglyceride （TG）, high-density lipoprotein cholesterol （HDL-C） ,low-density lipoprotein cholesterol （LDL-C）, Urine albumin excretion measured by ELISA were measured and compared between the normal blood pressure and high-normal blood pressure groups. Results Compared with normal blood pressure. The microalbuminuria is higher in the group of high-normal blood pressure （3.08±1.58 ）mg/L vs （3.86±1.7 ）mg/L,P〈0.01 ], however, CHO, TG, HDL-C, LDL-C, was not found difference in the two groups （P〉0.05）. Spearman correlation analysis showed microalbuminuria correlated negatively with blood pressure and fasting blood glucose SBP r=O.177,P〈O.O5,DBP r=O.252,P=O.O01 ,FBS r=O.279,P〈O.01. Adjusted age, sex, blood lipoprotein and BMI we received the same result, microalbuminuria levels were positively correlated with diastolic blood pressure and fasting blood glucose,SBP r=O.156,P=O.O55,DBP r=0.233,P〈0.05,FBS r= 0.251 ,P〈0.05. Conclusion （1）Compared with group of normal blood pressure,high-normal blood pressure group appears to be associated with higher microalbuminuria,fasting blood glucose, BMI but not CHO,TG, HDL-C,LDL-C. （2）The major factor influencing microalbuminuria（MAU ） was diastolic blood pressure and fasting blood glucose.