中国老年冠心病和尿酸水平相关性的荟萃分析

目的通过荟萃分析探讨中国老年人群冠心病发生与血尿酸水平的关系。方法从中国生物医学文献数据库和Pubmed等外文专业数据库中收录的1998年1月1日至2009年12月31日有关中国老年人群冠心病和尿酸水平相关分析文献中,纳入符合条件的文献,应用CHISS软件进行荟萃分析。结果针对中国老年人群进行的冠心病和血尿酸水平分析的研究存在异质性,荟萃分析得到尿酸水平与老年冠心病发生95%可信区间为-20.2248～31.7392,差异无统计学意义。结论荟萃分析未见中国老年人血尿酸升高与冠心病发生之间存在相关关系,多中心随机对照试验研究有望得到有关这一特定人群血尿酸水平与冠心病发生关系的确凿证据。

Meta-analysis on correlation between coronary heart disease and uric acid level in chinese elderly

Objective To investigate correlation between coronary heart disease and serum uric acid levels in Chinese eldly Through meta-analysis;Methods We searched Chinese biomedical literature databases and Pubmed and other foreign professional database from 1 January 1998 to 31 December 2009 and got all documents on relationships between coronary heart disease and uric acid level of Chinese eldly.Then we abstracted 11 documents according to our criteria and did meta-analysis with CHISS software;Results Herterogeneity was found among these 11 documents,and 95% confidence interval is-20.2248 ～ 31.7392,which means no statistically difference was found between coronary heart disease and serum uric acid levels in Chinese eldly Conclusion It seems that no correlation was found between elevation of serum uric acid level and coronary heart disease in Chinese eldly.Multi-center randomized controlled trials may be hopeful and helpful on this objective.