Studies of [3H]-7-(3-Butynyl)theophylline by whole-body autoradiography (author's transl)

Studies of ³H]-7-(3-Butynyl)theophylline by Whole-Body Autoradiography The synthesis of ³H]-7-(3-butynyl)-theophylline is described. Whole-body autoradiography of Wistar rats after application of the compound shows a cumulation of radioactivity in the cerebrospinal fluid, in the vitreous body of the eye and in the intervertebral discs. Histologic analysis of the kidney showed a vacuolic structure and partial destruction of the cells in convoluted tubules I and II.