| 红藻氨酸诱导癫痫发作大鼠海马结构中EAAC-1变化 |
| |
| 引用本文： | 夏峰,李臻,黄远桂,张远强.红藻氨酸诱导癫痫发作大鼠海马结构中EAAC-1变化[J].第四军医大学学报,2000,21(6):S107-S109. |
| |
| 作者姓名： | 夏峰 李臻 黄远桂 张远强 |
| |
| 作者单位： | 1. 第四军医大学,西京医院神经内科,陕西,西安,710033
2. 第四军医大学,组织学与胚胎学教研室,陕西,西安,710033 |
| |
| 摘 要： | 目的 研究谷氨酸转运蛋白亚型（ＥＡＡＣ－１）在红藻氨酸（ＫＡ）诱导癫痫发作大鼠海马结构中的变化。方法 用红藻氨酸诱导的复杂部分性癫痫模型,将２０只ＳＤ大鼠随机分为３,６,１２,４８ｈ及对照５组,用免疫蛋白印记法（Ｗｅｓｔｅｒｎ ｂｌｏｔ）观察ＥＡＡＣ－１在海马结构上的变化。结果 ＫＡ注射后３ｈ海马ＥＡＡＣ－１开始减少,６ｈ显著减少,１２ｈ后ＥＡＡＣ－１逐渐恢复。结论 ＥＡＡＣ－１表达的调控可能与Ｋ
|
| 关 键 词： | 癫痫 转运蛋白 谷氨酸 红藻氨酸 |
Changes of EAAC-1 in rat hippocampus following kainate-induced seizure activity |
| |
| XIA Feng,LI Zhen,ZHANG Yuan-Qiang,HUANG Yuan-Gui.Changes of EAAC-1 in rat hippocampus following kainate-induced seizure activity[J].Journal of the Fourth Military Medical University,2000,21(6):S107-S109. |
| |
| Authors: | XIA Feng LI Zhen ZHANG Yuan-Qiang HUANG Yuan-Gui |
| |
| Abstract: | AIM To study excitatory amino acid carrier 1(EAAC 1) in hippocampus of rats with seizure induced by kainate. METHODS A kainate induced complex partial seizure model was used in present study. 20 SD rats were randomly grouped into KA 3, 6, 12, 48 h and control. Changes of EAAC 1 protein in the rat hippocampus were observed by Western blots. RESULTS EAAC 1 protein decreased after the injection of kainate for 3 h, and decreased more significantly after 6 h while EAAC 1 protein increased after 12 h. CONCLUSION Regulation of EAAC 1 may play a role in kainate induced seizure, neurotoxicity and neuronal plasticity. |
| |
| Keywords: | seizure transporter glutamate kainic acid |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
