人参果皂苷对急性心肌梗塞犬冠状动脉循环及心肌氧代谢的影响

目的：研究人参果皂苷（ginseng fruit saponins,GFS）对急性心肌梗塞犬冠脉循环及心肌 氧代谢的影响。方法：犬结扎左冠状动脉前降支6 h造成急性心肌梗塞模型，同时静脉滴注GFS进行治疗，通过MP-27型电磁流量计记录冠状动脉血流量，以CORNIHG 178型血气分析仪测定动、静脉血 氧含量，观察心肌氧代谢变化。结果：与心肌梗塞模型组比较，静脉滴注GFS 5和10 mg·kg^-1，可使急性心肌梗塞6 h犬心肌血流量明显增加，冠脉血管阻力明显降低（P<0.05或P<0.01），并能使心肌氧利用率及心肌耗氧量明显降低（P<0.05或P<0.01），对心肌耗氧指数无明显影响（P>0.05）。 结论：GFS 可通过改善冠脉循环，增加心肌血液供给，同时降低心肌耗氧及降低心肌氧利用率发挥抗急性心肌缺血作用。

Effects of ginseng fruit saponins (GFS) on coronary circulation and myocardial oxygen metabolism in dogs with acute myocardial infarction

Objective To study the effects of ginseng fruit saponins(GFS)on the coronary circulation and cardial oxygen metabolism in dogs with acute myocardial infarction.Methods The acute myocardial infarction model was induced by ligating the left anterior descending coronary of dogs for 6 h.90 min after treatment with GFS,the blood flow of coronary artery was determined by using electromagnetism flowmeter with MP-27 type.At the same time,the blood oxygen contents of artery and vein were determined by using analysis instrument of blood gas with CORNIHG 178 type.Results After treated by GFS(in a dosage of 5 and 10 mg·kg~(-1) iv drip for 90 min),the myocardial blood flow(MBF) was increased and coronary vascular resistance(CVR) was decreased significantly.Meanwhile the cardiac oxygen consumption and myocardial oxygen utilization rate were also decreased,but cardiac oxygen consumption index had not changed significantly.Conclusion GFS has protective effects on acute myocardial ischemia through improving the coronary circulation,increasing myocardial blood supply and decreasing cardiac oxygen consumption and myocardial oxygen utilization rate.