| 卡托普利控释微丸的研制及其体外释放研究 |
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| 引用本文： | 张淑秋,冷光.卡托普利控释微丸的研制及其体外释放研究[J].山西医科大学学报,1997,28(1):16-18. |
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| 作者姓名： | 张淑秋 冷光 |
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| 作者单位： | 山西医科大学药剂学教研室，山西医科大学第一临床医学院药剂科 |
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| 摘 要： | 采用乙基纤维素、丙烯酸树脂Ⅱ及硬脂醇为缓释材料，研究了卡托普利控释微丸的处方和工艺。经体外释放实验证明，制得的控释微丸能明显延缓药物释放，释放过程符合零级动力学。
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| 关 键 词： | 卡托普利 迟效制剂 微丸 累积释放量 |
Studies on captopril controlled release pellets and their release process |
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| Zhang Shuqiu,Leng Guang,Xie Yin et al.Studies on captopril controlled release pellets and their release process[J].Journal of Shanxi Medical University,1997,28(1):16-18. |
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| Authors: | Zhang Shuqiu Leng Guang Xie Yin |
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| Abstract: | Captopril controlled release pellets were prepared by using ethyl cellulose,eudrigit L100 and stearyl alcohol.The studies on release process in vitro revealed that the release of captopril from pellets was retarded significantly and the release process followed the zero order kinetics. |
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| Keywords: | captopril delayed action preparations pellets cumulative release percentage |
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