| 微生物来源的新抗菌肽 |
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| 引用本文： | 恽冬杰,顾觉奋. 微生物来源的新抗菌肽[J]. 抗感染药学, 2006, 3(4): 149-153 |
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| 作者姓名： | 恽冬杰 顾觉奋 |
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| 作者单位： | 中国药科大学,生命科学与技术学院,南京,210009;中国药科大学,生命科学与技术学院,南京,210009 |
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| 摘 要： | 抗生素在临床上的广泛应用,导致耐药性问题日益严重。而肽类抗菌药作用机制独特,具有抗真菌、抗病毒、抗肿瘤活性,且不易产生耐药性,因此抗菌肽的研究已经日益深入。目前人们已从哺乳动物、植物、昆虫及微生物中分离得到抗菌肽,其中微生物来源的抗菌肽是抗菌肽家族的重要的成员。本文概述几种微生物来源的新抗菌肽,重点介绍目前已进入Ⅲ期临床试验的一种糖肽类抗菌肽Oritavancin。
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| 关 键 词： | 抗菌肽 作用机制 奥利万星(LY333328) 抗菌活性 |
| 文章编号： | 1672-7878（2006）04-0149-05 |
| 收稿时间： | 2006-07-04 |
| 修稿时间： | 2006-08-14 |
Advance in Novel Antimicrobial Peptides from Microorganisms |
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| YUN Dong-jie,GU Jue-fen. Advance in Novel Antimicrobial Peptides from Microorganisms[J]. Anti-infection Pharmacy, 2006, 3(4): 149-153 |
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| Authors: | YUN Dong-jie GU Jue-fen |
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| Affiliation: | Institute of Life Science and Technology ,China Pharmaceutical Univercity, Nanjing 210009, China |
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| Abstract: | Antimicrobial peptides (AMPs) have possessed unique mechanism of action, exhibited broad-spectrum activity against a wide range of microorganisms including Gram-positive and Gram-negative bacteria, protozoa, yeast, fungi, viruses and tumour cells. In addition, the resistant was not easy to produce. Recently, AMPs have been isolated from a wide variety of animals and plants as well as bacteria and fungi. The various novel antimicrobial peptides from microorganisms were described and paid attention to a semisynthetic glycopeptide antibiotic oritavancin (LY333328). It is currently in phase III clinical trials. |
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| Keywords: | Antimicrobial peptides mechanism of action oritavancin (Ly333328) antimicrobial activity |
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